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Diagnostic potentia...
Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer
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- Jain, S. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Nadeem, N. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Ulfenborg, Benjamin, 1985- (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translationell bioinformatik, Translational Bioinformatics
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- Makela, M. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Ruma, S. A. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Terava, J. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Huhtinen, K. (author)
- Institute of Biomedicine and FICAN West Cancer Centre, University of Turku and Turku University Hospital, Finland ; Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, University of Helsinki, Finland
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- Leivo, J. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Kristjansdottir, Björg (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Sweden
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- Pettersson, K. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Sweden
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- Gidwani, K. (author)
- Department of Life Technologies and FICAN West Cancer Centre, University of Turku, Finland
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(creator_code:org_t)
- 2022-05-25
- 2022
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 151:7, s. 1175-1184
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Abstract
Subject headings
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- Our study reports the discovery and evaluation of nanoparticle aided sensitive assays for glycovariants of MUC16 and MUC1 in a unique collection of paired ovarian cyst fluids and serum samples obtained at or prior to surgery for ovarian carcinoma suspicion. Selected glycovariants and the immunoassays for CA125, CA15-3 and HE4 were compared and validated in 347 cyst fluid and serum samples. Whereas CA125 and CA15-3 performed poorly in cyst fluid to separate carcinoma and controls, four glycovariants including MUC16(MGL), MUC16(STn), MUC1(STn) and MUC1(Tn) provided highly improved separations. In serum, the two STn glycovariants outperformed conventional CA125, CA15-3 and HE4 assays in all subcategories analyzed with main benefits obtained at high specificities and at postmenopausal and early-stage disease. Serum MUC16(STn) performed best at high specificity (90%-99%), but sensitivity was also improved by the other glycovariants and CA15-3. The highly improved specificity, excellent analytical sensitivity and robustness of the nanoparticle assisted glycovariant assays carry great promise for improved identification and early detection of ovarian carcinoma in routine differential diagnostics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- diagnosis
- epithelial ovarian cancer
- europium nanoparticle
- mucins
- STn
- protein glycosylation
- biomarkers
- ca125
- expression
- glycans
- he-4
- tn
- Oncology
- STn
- Bioinformatik
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jain, S.
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Nadeem, N.
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Ulfenborg, Benja ...
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Makela, M.
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Ruma, S. A.
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Terava, J.
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Huhtinen, K.
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Leivo, J.
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Kristjansdottir, ...
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Pettersson, K.
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Sundfeldt, Karin ...
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Gidwani, K.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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University of Gothenburg
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University of Skövde