Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

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Jami, E. S. (author)

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Article/chapterEnglish2022

Publisher, publication year, extent ...

Elsevier BV,2022

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/319226
https://gup.ub.gu.se/publication/319226URI
https://doi.org/10.1016/j.jaac.2021.11.035DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150405940URI

Supplementary language notes

Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument. Results: The meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, n(effective) = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (vertical bar r(g)vertical bar > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range vertical bar r(g)vertical bar = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa. Conclusion: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
depression
anxiety
repeated measures
genetic epidemiology
molecular
genetics
major depressive disorder
behavioral-problems
mental-disorders
anxiety
children
psychopathology
questionnaire
heritability
prevalence
risk
Psychology
Pediatrics
Psychiatry

Added entries (persons, corporate bodies, meetings, titles ...)

Hammerschlag, A. R. (author)
Ip, H. F. (author)
Allegrini, A. G. (author)
Benyamin, B. (author)
Border, R. (author)
Diemer, E. W. (author)
Jiang, C. (author)
Karhunen, V. (author)
Lu, Y.Karolinska Institutet (author)
Lu, Q. (author)
Mallard, T. T. (author)
Mishra, P. P. (author)
Nolte, I. M. (author)
Palviainen, T. (author)
Peterson, R. E. (author)
Sallis, H. M. (author)
Shabalin, A. A. (author)
Tate, A. E.Karolinska Institutet (author)
Thiering, E. (author)
Vilor-Tejedor, N. (author)
Wang, C. (author)
Zhou, A. (author)
Adkins, D. E. (author)
Alemany, S. (author)
Ask, H. (author)
Chen, Q. (author)
Corley, R. P. (author)
Ehli, E. A. (author)
Evans, L. M. (author)
Havdahl, A. (author)
Hagenbeek, F. A. (author)
Hakulinen, C. (author)
Henders, A. K. (author)
Hottenga, J. J. (author)
Korhonen, T. (author)
Mamun, A. (author)
Marrington, S. (author)
Neumann, A. (author)
Rimfeld, K.Karolinska Institutet (author)
Rivadeneira, F. (author)
Silberg, J. L. (author)
van Beijsterveldt, C. E. (author)
Vuoksimaa, E. (author)
Whipp, A. M. (author)
Tong, X. R. (author)
Andreassen, O. A. (author)
Boomsma, D. I. (author)
Brown, S. A. (author)
Burt, S. A. (author)
Copeland, W. (author)
Dick, D. M. (author)
Harden, K. P. (author)
Harris, K. M. (author)
Hartman, C. A. (author)
Heinrich, J. (author)
Hewitt, J. K. (author)
Hopfer, C. (author)
Hypponen, E. (author)
Jarvelin, M. R. (author)
Kaprio, J. (author)
Keltikangas-Jarvinen, L. (author)
Klump, K. L. (author)
Krauter, K. (author)
Kuja-Halkola, R. (author)
Larsson, H. (author)
Lehtimaki, T. (author)
Lichtenstein, P.Karolinska Institutet (author)
Lundström, SebastianGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xluseb (author)
Maes, H. H. (author)
Magnus, P. (author)
Munafo, M. R. (author)
Najman, J. M. (author)
Njolstad, P. R. (author)
Oldehinkel, A. J. (author)
Pennell, C. E. (author)
Plomin, R. (author)
Reichborn-Kjennerud, T. (author)
Reynolds, C. (author)
Rose, R. J. (author)
Smolen, A. (author)
Snieder, H. (author)
Stallings, M. (author)
Standl, M. (author)
Sunyer, J. (author)
Tiemeier, H. (author)
Wadsworth, S. J. (author)
Wall, T. L. (author)
Whitehouse, A. J. O. (author)
Williams, G. M. (author)
Ystrom, E. (author)
Nivard, M. G. (author)
Bartels, M. (author)
Middeldorp, C. M. (author)
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

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In:Journal of the American Academy of Child and Adolescent Psychiatry: Elsevier BV61:7, s. 934-9450890-85671527-5418

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By the author/editor: Jami, E. S.; Hammerschlag, A. ...; Ip, H. F.; Allegrini, A. G.; Benyamin, B.; Border, R.; show more...; Diemer, E. W.; Jiang, C.; Karhunen, V.; Lu, Y.; Lu, Q.; Mallard, T. T.; Mishra, P. P.; Nolte, I. M.; Palviainen, T.; Peterson, R. E.; Sallis, H. M.; Shabalin, A. A.; Tate, A. E.; Thiering, E.; Vilor-Tejedor, N ...; Wang, C.; Zhou, A.; Adkins, D. E.; Alemany, S.; Ask, H.; Chen, Q.; Corley, R. P.; Ehli, E. A.; Evans, L. M.; Havdahl, A.; Hagenbeek, F. A.; Hakulinen, C.; Henders, A. K.; Hottenga, J. J.; Korhonen, T.; Mamun, A.; Marrington, S.; Neumann, A.; Rimfeld, K.; Rivadeneira, F.; Silberg, J. L.; van Beijsterveld ...; Vuoksimaa, E.; Whipp, A. M.; Tong, X. R.; Andreassen, O. A ...; Boomsma, D. I.; Brown, S. A.; Burt, S. A.; Copeland, W.; Dick, D. M.; Harden, K. P.; Harris, K. M.; Hartman, C. A.; Heinrich, J.; Hewitt, J. K.; Hopfer, C.; Hypponen, E.; Jarvelin, M. R.; Kaprio, J.; Keltikangas-Jarv ...; Klump, K. L.; Krauter, K.; Kuja-Halkola, R.; Larsson, H.; Lehtimaki, T.; Lichtenstein, P.; Lundström, Sebas ...; Maes, H. H.; Magnus, P.; Munafo, M. R.; Najman, J. M.; Njolstad, P. R.; Oldehinkel, A. J ...; Pennell, C. E.; Plomin, R.; Reichborn-Kjenne ...; Reynolds, C.; Rose, R. J.; Smolen, A.; Snieder, H.; Stallings, M.; Standl, M.; Sunyer, J.; Tiemeier, H.; Wadsworth, S. J.; Wall, T. L.; Whitehouse, A. J ...; Williams, G. M.; Ystrom, E.; Nivard, M. G.; Bartels, M.; Middeldorp, C. M ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: Journal of the A ...

By the university: University of Gothenburg; Karolinska Institutet

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