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Mechanical strain s...
Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1
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Phuyal, S. (author)
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Djaerff, E. (author)
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Le Roux, A. L. (author)
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Baker, M. J. (author)
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Fankhauser, D. (author)
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- Mahdizadeh, Sayyed Jalil (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Reiterer, V. (author)
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Parizadeh, A. (author)
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Felder, E. (author)
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Kahlhofer, J. C. (author)
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Teis, D. (author)
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Kazanietz, M. G. (author)
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Geley, S. (author)
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- Eriksson, Leif A, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Roca-Cusachs, P. (author)
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Farhan, H. (author)
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(creator_code:org_t)
- 2022-08-08
- 2022
- English.
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In: Embo Journal. - : EMBO. - 0261-4189 .- 1460-2075. ; 41:18
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Abstract
Subject headings
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- Cells are constantly exposed to various chemical and physical stimuli. While much has been learned about the biochemical factors that regulate secretory trafficking from the endoplasmic reticulum (ER), much less is known about whether and how this trafficking is subject to regulation by mechanical signals. Here, we show that subjecting cells to mechanical strain both induces the formation of ER exit sites (ERES) and accelerates ER-to-Golgi trafficking. We found that cells with impaired ERES function were less capable of expanding their surface area when placed under mechanical stress and were more prone to develop plasma membrane defects when subjected to stretching. Thus, coupling of ERES function to mechanotransduction appears to confer resistance of cells to mechanical stress. Furthermore, we show that the coupling of mechanotransduction to ERES formation was mediated via a previously unappreciated ER-localized pool of the small GTPase Rac1. Mechanistically, we show that Rac1 interacts with the small GTPase Sar1 to drive budding of COPII carriers and stimulates ER-to-Golgi transport. This interaction therefore represents an unprecedented link between mechanical strain and export from the ER.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- COPII
- endoplasmic reticulum
- mechanobiology
- fast interaction refinement
- reticulum exit sites
- endoplasmic-reticulum
- web server
- protein
- gtpase
- docking
- cells
- er
- proliferation
- Biochemistry & Molecular Biology
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Phuyal, S.
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Djaerff, E.
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Le Roux, A. L.
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Baker, M. J.
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Fankhauser, D.
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Mahdizadeh, Sayy ...
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show more...
-
Reiterer, V.
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Parizadeh, A.
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Felder, E.
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Kahlhofer, J. C.
-
Teis, D.
-
Kazanietz, M. G.
-
Geley, S.
-
Eriksson, Leif A ...
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Roca-Cusachs, P.
-
Farhan, H.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Embo Journal
- By the university
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University of Gothenburg