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Cross-Sectional Ass...
Cross-Sectional Associations of CSF Tau Levels With Rey's AVLT: A Recency Ratio Study
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Bruno, D. (author)
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Zinkunegi, A. J. (author)
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Pomara, N. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Koscik, R. L. (author)
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Carlsson, C. (author)
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Bendlin, B. (author)
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Okonkwo, O. (author)
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Hermann, B. P. (author)
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Johnson, S. C. (author)
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Mueller, K. D. (author)
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(creator_code:org_t)
- 2022-05-23
- 2023
- English.
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In: Neuropsychology. - : American Psychological Association (APA). - 0894-4105 .- 1931-1559. ; 37:6, s. 628-635
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: The preeminent in vivo cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are amyloid beta 1-42 (A1342), phosphorylated Tau (p-tau), and total Tau (t-tau). The goal of this study was to examine how well traditional (total and delayed recall) and process-based (recency ratio [Rr]) measures derived from Rey's Auditory Verbal Learning test (AVLT) were associated with these biomarkers. Method: Data from 235 participants (M-age = 65.5, SD = 6.9), who ranged from cognitively unimpaired to mild cognitive impairment, and for whom CSF values were available, were extracted from the Wisconsin Registry for Alzheimer's Prevention. Bayesian regression analyses were carried out using CSF scores as outcomes, AVLT scores as predictors, and controlling for demographic data and diagnosis. Results: We found moderate evidence that Rr was associated with both CSF p-tau (Bayesian factor [BFM] = 5.55) and t-tau (BFM = 7.28), above and beyond the control variables, while it did not correlate with CSF A1342 levels. In contrast, total and delayed recall scores were not linked with any of the AD biomarkers, in separate analyses. When comparing all memory predictors in a single regression, Rr remained the strongest predictor of CSF t-tau levels (BFM = 3.57). Conclusions: Our findings suggest that Rr may be a better cognitive measure than commonly used AVLT scores to assess CSF levels of p-tau and t-tau in nondemented individuals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- A/T/N biomarkers
- Alzheimer's disease
- CSF tau
- CSF A beta 42
- recency
- ratio
- mild cognitive impairment
- white-matter hyperintensity
- alzheimers-disease
- african-americans
- diagnostic guidelines
- wisconsin-registry
- national institute
- recall
- recommendations
- performance
- Psychology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bruno, D.
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Zinkunegi, A. J.
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Pomara, N.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Koscik, R. L.
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show more...
-
Carlsson, C.
-
Bendlin, B.
-
Okonkwo, O.
-
Hermann, B. P.
-
Johnson, S. C.
-
Mueller, K. D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuropsychology
- By the university
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University of Gothenburg