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Routine revasculari...
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Sabbah, MuhammadCopenhagen University Hospital
(author)
Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation - the third Nordic Aortic Valve Intervention Trial - NOTION-3.
- Article/chapterEnglish2022
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LIBRIS-ID:oai:gup.ub.gu.se/319363
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https://gup.ub.gu.se/publication/319363URI
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https://doi.org/10.1016/j.ahj.2022.10.009DOI
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https://lup.lub.lu.se/record/f7af0fe4-390b-4484-999f-7026d1011641URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:236220354URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153815090URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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gratis
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Coronary artery disease (CAD) frequently coexists with severe aortic valve stenosis (AS) in patients planned for transcatheter aortic valve implantation (TAVI). How to manage CAD in this patient population is still an unresolved question. In particular, it is still not known whether fractional flow reserve (FFR) guided revascularization with percutaneous coronary intervention (PCI) is superior to medical treatment for CAD in terms of clinical outcomes.The third Nordic Aortic Valve Intervention (NOTION-3) Trial is an open-label investigator-initiated, multicenter multinational trial planned to randomize 452 patients with severe AS and significant CAD to either FFR-guided PCI or medical treatment, in addition to TAVI. Patients are eligible for the study in the presence of at least one significant PCI-eligible coronary stenosis. A significant stenosis is defined as either FFR ≤0.80 and/or diameter stenosis >90%. The primary endpoint is a composite of first occurring all-cause mortality, myocardial infarction, or urgent revascularization (PCI or coronary artery bypass graft performed during unplanned hospital admission) until the last included patient have been followed for 1 year after the TAVI.NOTION-3 is a multicenter, multinational randomized trial aiming at comparing FFR-guided revascularization vs medical treatment of CAD in patients with severe AS planned for TAVI.
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Veien, KarstenOdense University Hospital
(author)
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Niemela, MattiOulu University Hospital
(author)
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Freeman, PhillipAalborg University Hospital
(author)
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Linder, RickardKarolinska Institutet,Danderyd Hospital
(author)
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Ioanes, DanGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital
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Terkelsen, Christian JuhlDanish Heart Foundation,Aarhus University Hospital
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Kajander, Olli AHelsinki University Central Hospital,University of Helsinki
(author)
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Koul, SashaLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-sku
(author)
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Savontaus, MikkoTurku University Hospital
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Karjalainen, PasiUniversity of Helsinki,Helsinki University Central Hospital
(author)
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Erglis, AndrejsUniversity of Latvia
(author)
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Minkkinen, MikkoUniversity of Helsinki,Helsinki University Central Hospital
(author)
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Jørgensen, TroelsCopenhagen University Hospital
(author)
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Sondergaard, LarsCopenhagen University Hospital,University of Copenhagen
(author)
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De Backer, OleCopenhagen University Hospital
(author)
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Engstrøm, ThomasUniversity of Copenhagen,Copenhagen University Hospital
(author)
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Lønborg, JacobCopenhagen University Hospital
(author)
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Copenhagen University HospitalOdense University Hospital
(creator_code:org_t)
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Göteborgs universitet
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Gothenburg University
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In:American heart journal: Elsevier BV1097-67440002-8703
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Sabbah, Muhammad
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Veien, Karsten
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Niemela, Matti
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Freeman, Phillip
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Linder, Rickard
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Ioanes, Dan
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Terkelsen, Chris ...
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Kajander, Olli A
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Koul, Sasha
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Savontaus, Mikko
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Karjalainen, Pas ...
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Erglis, Andrejs
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Minkkinen, Mikko
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Jørgensen, Troel ...
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Sondergaard, Lar ...
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De Backer, Ole
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Engstrøm, Thomas
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Lønborg, Jacob
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