onr:"swepub:oai:gup.ub.gu.se/319948"
Search: onr:"swepub:oai:gup.ub.gu.se/319948" > Galectin-3 is eleva...
- 1 of 1
- Previous record
- Next record
- To hitlist
Galectin-3 is elevated in CSF and is associated with A beta deposits and tau aggregates in brain tissue in Alzheimer's disease
- Boza-Serrano, A. (author)
- Vrillon, A. (author)
-
- Minta, Karolina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
- show more...
- Paulus, A. (author)
- Camprubi-Ferrer, L. (author)
- Garcia, M. (author)
- Antonell, A. (author)
- Wennstrom, M. (author)
- Gouras, G. (author)
- Dumurgier, J. (author)
- Cognat, E. (author)
- Molina-Porcel, L. (author)
- Balasa, M. (author)
- Vitorica, J. (author)
- Sanchez-Valle, R. (author)
- Paquet, C. (author)
- Venero, J. L. (author)
- Deierborg, T. (author)
- show less...
- (creator_code:org_t)
- 2022-07-27
- 2022
- English.
- In: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533.
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Galectin-3 (Gal-3) is a beta-galactosidase binding protein involved in microglial activation in the central nervous system (CNS). We previously demonstrated the crucial deleterious role of Gal-3 in microglial activation in Alzheimer's disease (AD). Under AD conditions, Gal-3 is primarily expressed by microglial cells clustered around A beta plaques in both human and mouse brain, and knocking out Gal-3 reduces AD pathology in AD-model mice. To further unravel the importance of Gal-3-associated inflammation in AD, we aimed to investigate the Gal-3 inflammatory response in the AD continuum. First, we measured Gal-3 levels in neocortical and hippocampal tissue from early-onset AD patients, including genetic and sporadic cases. We found that Gal-3 levels were significantly higher in both cortex and hippocampus in AD subjects. Immunohistochemistry revealed that Gal-3+ microglial cells were associated with amyloid plaques of a larger size and more irregular shape and with neurons containing tau-inclusions. We then analyzed the levels of Gal-3 in cerebrospinal fluid (CSF) from AD patients (n=119) compared to control individuals (n= 36). CSF Gal-3 levels were elevated in AD patients compared to controls and more strongly correlated with tau (p-Tau181 and t-tau) and synaptic markers (GAP-43 and neurogranin) than with amyloid-beta. Lastly, principal component analysis (PCA) of AD biomarkers revealed that CSF Gal-3 clustered and associated with other CSF neuroinflammatory markers, including sTREM-2, GFAP, and YKL-40. This neuroinflammatory component was more highly expressed in the CSF from amyloid-beta positive (A+), CSF p-Tau181 positive (T+), and biomarker neurodegeneration positive/negative (N+/-) (A + T +N+/-) groups compared to the A + T-N- group. Overall, Gal-3 stands out as a key pathological biomarker of AD pathology that is measurable in CSF and, therefore, a potential target for disease-modifying therapies involving the neuroinflammatory response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- microglia
- receptor
- pathway
- strem2
- Neurosciences & Neurology
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Acta Neuropathologica (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Boza-Serrano, A.
- Vrillon, A.
- Minta, Karolina
- Paulus, A.
- Camprubi-Ferrer, ...
- Garcia, M.
- show more...
- Andreasson, Ulf, ...
- Antonell, A.
- Wennstrom, M.
- Gouras, G.
- Dumurgier, J.
- Cognat, E.
- Molina-Porcel, L ...
- Balasa, M.
- Vitorica, J.
- Sanchez-Valle, R ...
- Paquet, C.
- Venero, J. L.
- Blennow, Kaj, 19 ...
- Deierborg, T.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Acta Neuropathol ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
