Search: onr:"swepub:oai:gup.ub.gu.se/319956" >
The Alzheimer's Ass...
The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease
-
- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
-
- Edelmayer, R. M. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
-
- Boxer, A. L. (author)
- University of California, San Francisco
-
show more...
-
- Carrillo, M. C. (author)
- Alzheimer's Association: Alzheimer's Disease and Dementia
-
- Mielke, M. M. (author)
- Wake Forest University
-
- Rabinovici, G. D. (author)
- University of California, San Francisco
-
- Salloway, S. (author)
- Brown University
-
- Sperling, R. (author)
- Harvard Medical School
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University College London,Sahlgrenska University Hospital,Sahlgrenska Academy
-
- Teunissen, C. E. (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
show less...
-
(creator_code:org_t)
- 2022-07-31
- 2022
- English.
-
In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:12, s. 2669-2686
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- appropriate use recommendations
- blood-based
- biomarkers
- diagnosis
- prognosis
- plasma neurofilament light
- fibrillary acidic protein
- phosphorylated
- tau 181
- amyloid-beta
- clinical-diagnosis
- dementia
- accuracy
- performance
- prevalence
- validation
- Neurosciences & Neurology
- blood-based biomarkers
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Hansson, Oskar
-
Edelmayer, R. M.
-
Boxer, A. L.
-
Carrillo, M. C.
-
Mielke, M. M.
-
Rabinovici, G. D ...
-
show more...
-
Salloway, S.
-
Sperling, R.
-
Zetterberg, Henr ...
-
Teunissen, C. E.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Alzheimers & Dem ...
- By the university
-
University of Gothenburg
-
Lund University