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The Alzheimer's Ass...
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
(author)
The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease
- Article/chapterEnglish2022
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LIBRIS-ID:oai:gup.ub.gu.se/319956
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https://gup.ub.gu.se/publication/319956URI
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https://doi.org/10.1002/alz.12756DOI
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https://lup.lub.lu.se/record/17ea2e62-a813-4d7c-a613-d3fe69d0cecfURI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.
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Edelmayer, R. M.Alzheimer's Association: Alzheimer's Disease and Dementia
(author)
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Boxer, A. L.University of California, San Francisco
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Carrillo, M. C.Alzheimer's Association: Alzheimer's Disease and Dementia
(author)
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Mielke, M. M.Wake Forest University
(author)
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Rabinovici, G. D.University of California, San Francisco
(author)
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Salloway, S.Brown University
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Sperling, R.Harvard Medical School
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University College London,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-hiz
(author)
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Teunissen, C. E.Academic Medical Center of University of Amsterdam (AMC)
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Klinisk minnesforskningForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Alzheimers & Dementia: Wiley18:12, s. 2669-26861552-52601552-5279
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Hansson, Oskar
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Edelmayer, R. M.
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Boxer, A. L.
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Carrillo, M. C.
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Mielke, M. M.
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Rabinovici, G. D ...
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show more...
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Salloway, S.
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Sperling, R.
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Zetterberg, Henr ...
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Teunissen, C. E.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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Alzheimers & Dem ...
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University of Gothenburg
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Lund University