Search: onr:"swepub:oai:gup.ub.gu.se/320116" >
Association of Lipi...
-
O'Donnell, Martin J
(author)
Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE).
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
Korean Stroke Society,2022
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/320116
-
https://gup.ub.gu.se/publication/320116URI
-
https://doi.org/10.5853/jos.2021.02152DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The association of dyslipidemia with stroke has been inconsistent, which may be due to differing associations within etiological stroke subtypes. We sought to determine the association of lipoproteins and apolipoproteins within stroke subtypes.Standardized incident case-control STROKE study in 32 countries. Cases were patients with acute hospitalized first stroke, and matched by age, sex and site to controls. Concentrations of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1), and apoB were measured. Non-HDL-C was calculated. We estimated multivariable odds ratio (OR) and population attributable risk percentage (PAR%). Outcome measures were all stroke, ischemic stroke (and subtypes), and intracerebral hemorrhage (ICH).Our analysis included 11,898 matched case-control pairs; 77.3% with ischemic stroke and 22.7% with ICH. Increasing apoB (OR, 1.10; 95% confidence interval [CI], 1.06 to 1.14 per standard deviation [SD]) and LDL-C (OR, 1.06; 95% CI, 1.02 to 1.10 per SD) were associated with an increase in risk of ischemic stroke, but a reduced risk of ICH. Increased apoB was significantly associated with large vessel stroke (PAR 13.4%; 95% CI, 5.6 to 28.4) and stroke of undetermined cause. Higher HDL-C (OR, 0.75; 95% CI, 0.72 to 0.78 per SD) and apoA1 (OR, 0.63; 95% CI, 0.61 to 0.66 per SD) were associated with ischemic stroke (and subtypes). While increasing HDL-C was associated with an increased risk of ICH (OR, 1.20; 95% CI, 1.14 to 1.27 per SD), apoA1 was associated with a reduced risk (OR, 0.80; 95% CI, 0.75 to 0.85 per SD). ApoB/A1 (OR, 1.38; 95% CI, 1.32 to 1.44 per SD) had a stronger magnitude of association than the ratio of LDL-C/HDL-C (OR, 1.26; 95% CI, 1.21 to 1.31 per SD) with ischemic stroke (P<0.0001).The pattern and magnitude of association of lipoproteins and apolipoproteins with stroke varies by etiological stroke subtype. While the directions of association for LDL, HDL, and apoB were opposing for ischemic stroke and ICH, apoA1 was associated with a reduction in both ischemic stroke and ICH. The ratio of apoB/A1 was the best lipid predictor of ischemic stroke risk.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
McQueen, Matthew
(author)
-
Sniderman, Allan
(author)
-
Pare, Guillaume
(author)
-
Wang, Xingyu
(author)
-
Hankey, Graeme J
(author)
-
Rangarajan, Sumathy
(author)
-
Chin, Siu Lim
(author)
-
Rao-Melacini, Purnima
(author)
-
Ferguson, John
(author)
-
Xavier, Denis
(author)
-
Lisheng, Liu
(author)
-
Zhang, Hongye
(author)
-
Pais, Prem
(author)
-
Lopez-Jaramillo, Patricio
(author)
-
Damasceno, Albertino
(author)
-
Langhorne, Peter
(author)
-
Rosengren, Annika,1951Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xrosan
(author)
-
Dans, Antonio L
(author)
-
Elsayed, Ahmed
(author)
-
Avezum, Alvaro
(author)
-
Mondo, Charles
(author)
-
Judge, Conor
(author)
-
Diener, Hans-Christoph
(author)
-
Ryglewicz, Danuta
(author)
-
Czlonkowska, Anna
(author)
-
Pogosova, Nana
(author)
-
Weimar, Christian
(author)
-
Iqbal, Romana
(author)
-
Diaz, Rafael
(author)
-
Yusoff, Khalid
(author)
-
Yusufali, Afzalhussein
(author)
-
Oguz, Aytekin
(author)
-
Penaherrera, Ernesto
(author)
-
Lanas, Fernando
(author)
-
Ogah, Okechukwu S
(author)
-
Ogunniyi, Adesola
(author)
-
Iversen, Helle K
(author)
-
Malaga, German
(author)
-
Rumboldt, Zvonko
(author)
-
Oveisgharan, Shahram
(author)
-
Al Hussain, Fawaz
(author)
-
Nilanont, Yongchai
(author)
-
Yusuf, Salim
(author)
-
Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
Related titles
-
In:Journal of stroke: Korean Stroke Society24:2, s. 224-2352287-63912287-6405
Internet link
Find in a library
To the university's database
- By the author/editor
-
O'Donnell, Marti ...
-
McQueen, Matthew
-
Sniderman, Allan
-
Pare, Guillaume
-
Wang, Xingyu
-
Hankey, Graeme J
-
show more...
-
Rangarajan, Suma ...
-
Chin, Siu Lim
-
Rao-Melacini, Pu ...
-
Ferguson, John
-
Xavier, Denis
-
Lisheng, Liu
-
Zhang, Hongye
-
Pais, Prem
-
Lopez-Jaramillo, ...
-
Damasceno, Alber ...
-
Langhorne, Peter
-
Rosengren, Annik ...
-
Dans, Antonio L
-
Elsayed, Ahmed
-
Avezum, Alvaro
-
Mondo, Charles
-
Judge, Conor
-
Diener, Hans-Chr ...
-
Ryglewicz, Danut ...
-
Czlonkowska, Ann ...
-
Pogosova, Nana
-
Weimar, Christia ...
-
Iqbal, Romana
-
Diaz, Rafael
-
Yusoff, Khalid
-
Yusufali, Afzalh ...
-
Oguz, Aytekin
-
Penaherrera, Ern ...
-
Lanas, Fernando
-
Ogah, Okechukwu ...
-
Ogunniyi, Adesol ...
-
Iversen, Helle K
-
Malaga, German
-
Rumboldt, Zvonko
-
Oveisgharan, Sha ...
-
Al Hussain, Fawa ...
-
Nilanont, Yongch ...
-
Yusuf, Salim
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Journal of strok ...
- By the university
-
University of Gothenburg