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Prognostic Value of...
Prognostic Value of Stromal Type IV Collagen Expression in Small Invasive Breast Cancers
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- Jansson, Malin (author)
- Umeå universitet,Kirurgi
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- Lindberg, J. (author)
- Umeå universitet,Kirurgi
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- Rask, Gunilla (author)
- Umeå universitet,Patologi
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- Svensson, Johan, 1978- (author)
- Umeå universitet,Statistik,Kirurgi
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- Billing, Ola, 1981- (author)
- Umeå universitet,Kirurgi
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- Nazemroaya, Anoosheh (author)
- Umeå universitet,Patologi
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- Berglund, Anette, 1960- (author)
- Umeå universitet,Kirurgi
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- Wärnberg, Fredrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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(creator_code:org_t)
- 2022-05-25
- 2022
- English.
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In: Frontiers in Molecular Biosciences. - : Frontiers Media SA. - 2296-889X. ; 9
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Abstract
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- Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basement membrane protein, and breach of this extracellular matrix structure is the first step of cancer invasion. Type IV collagen is found in the stroma of many cancers, but its role in tumor biology is unclear. Here, expression of type IV collagen in the stroma of small breast cancers was analyzed, correlated to clinically used prognostic biomarkers and patient survival. The findings were further validated in an independent gene expression data cohort. Tissue samples from 1,379 women with in situ and small invasive breast cancers (<= 15 mm) diagnosed in 1986-2004 were included. Primary tumor tissue was collected into tissue microarrays. Type IV collagen expression in tissues was visualized using immunohistochemistry. Gene expression data was extracted from the Cancer Genome Atlas database. Out of 1,379 women, 856 had an invasive breast cancer and type IV collagen staining was available for 714 patients. In Kaplan-Meier analysis high type IV collagen expression was significantly associated (p = 0.026) with poorer breast cancer specific survival. There was no correlation of type IV collagen expression to clinically used prognostic biomarkers. High type IV collagen expression was clearly associated to distant metastasis (p = 0.002). In an external validation cohort (n = 1,104), high type IV collagen mRNA expression was significantly (p = 0.041) associated with poorer overall survival, with overexpression of type IV collagen mRNA in metastatic tissue. Stromal type IV collagen expression in the primary tumor correlates to poor breast cancer specific survival most likely due to a higher risk of developing distant metastasis. This ECM protein may function as biomarker to predict the risk of future metastatic disease in patients with breast cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- type IV collagen
- breast cancer
- extracellular matrix
- tumor
- progression
- tumor microenvironment
- colorectal-cancer
- tumor invasion
- matrix
- chains
- subtypes
- Biochemistry & Molecular Biology
- breast cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jansson, Malin
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Lindberg, J.
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Rask, Gunilla
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Svensson, Johan, ...
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Billing, Ola, 19 ...
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Nazemroaya, Anoo ...
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show more...
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Berglund, Anette ...
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Wärnberg, Fredri ...
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Sund, Malin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Frontiers in Mol ...
- By the university
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University of Gothenburg
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Umeå University