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Advances in the Syn...
Advances in the Synthesis of Enterobactin, Artificial Analogues, and Enterobactin-Derived Antimicrobial Drug Conjugates and Imaging Tools for Infection Diagnosis
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- Klahn, Philipp (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Zscherp, R. (author)
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Jimidar, C. C. (author)
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(creator_code:org_t)
- 2022-05-17
- 2022
- English.
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In: Synthesis-Stuttgart. - : Georg Thieme Verlag KG. - 0039-7881. ; 54:16, s. 3499-3557
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Abstract
Subject headings
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- Iron is an essential growth factor for bacteria, but although highly abundant in nature, its bioavailability during infection in the human host or the environment is limited. Therefore, bacteria produce and secrete siderophores to ensure their supply of iron. The triscatecholate siderophore enterobactin and its glycosylated derivatives, the salmochelins, play a crucial role for iron acquisition in several bacteria. As these compounds can serve as carrier molecules for the design of antimicrobial siderophore drug conjugates as well as siderophore-derived tool compounds for the detection of infections with bacteria, their synthesis and the design of artificial analogues is of interest. In this review, we give an overview on the synthesis of enterobactin, biomimetic as well as totally artificial analogues, and related drug-conjugates covering up to 12/2021.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- enterobactin
- salmochelins
- microcins
- siderophores
- drug conjugates
- catecholates
- tris -lactone
- iron(III) chelator
- ion sequestering agents
- microbial iron transport
- beta-lactam
- antibiotics
- escherichia-coli strains
- in-vitro antibacterial
- mri
- contrast agents
- ferric-enterobactin
- catecholate-siderophore
- outer-membrane
- microcin e492
- Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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