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Dysregulation of va...
Dysregulation of vascular endothelial growth factor receptor 2 phosphorylation is associated with disruption of the blood-brain barrier and brain endothelial cell apoptosis induced by plasma from women with preeclampsia
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- Torres-Vergara, P. (author)
- Univ Concepcion, Fac Pharm, Dept Pharm, Concepcion, Chile.;Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile.
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- Troncoso, F. (author)
- Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile.;Univ Bio Bio, Fac Sci, Dept Basic Sci, Vasc Physiol Lab, Chillan, Chile.
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- Acurio, J. (author)
- Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile.;Univ Bio Bio, Fac Sci, Dept Basic Sci, Vasc Physiol Lab, Chillan, Chile.
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- Kupka, Ellen (author)
- Uppsala universitet,Centrum för klinisk forskning Dalarna
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- Bergman, Lina, 1982 (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Centrum för klinisk forskning Dalarna,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynecol, Stellenbosch, South Africa.;Gothenburg Univ, Sahlgrenska Acad, Dept Clin Sci, Gothenburg, Sweden.
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- Wikström, Anna-Karin, 1965- (author)
- Uppsala universitet,Klinisk obstetrik
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- Escudero, C. (author)
- Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile.;Univ Bio Bio, Fac Sci, Dept Basic Sci, Vasc Physiol Lab, Chillan, Chile.
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Univ Concepcion, Fac Pharm, Dept Pharm, Concepcion, Chile;Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile. Grp Res & Innovat Vasc Hlth GR Hlth, Chillan, Chile.;Univ Bio Bio, Fac Sci, Dept Basic Sci, Vasc Physiol Lab, Chillan, Chile. (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Biochimica Et Biophysica Acta-Molecular Basis of Disease. - : Elsevier BV. - 0925-4439 .- 1879-260X. ; 1868:9
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Abstract
Subject headings
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- Disruption of the blood-brain barrier (BBB) is central in the pathophysiology of acute cerebral complications in women who have preeclampsia. Underling mechanisms are unclear. Using female human brain endothelial cells as an in vitro model of BBB, we show that plasma of women with preeclampsia increases cell apoptosis and permeability via activation of the vascular endothelial growth factor receptor 2 (VEGFR2). Since plasma of women with preeclampsia also enhanced VEGFR2 phosphorylation in the tyrosine 951 but decreased phosphorylation at the tyrosine 1175, we propose the former would be the more likely active form of VEGFR2 responsible for BBB alterations.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Preeclampsia
- Blood-brain barrier
- Vascular endothelial growth factor
- receptors
- Permeability
- Apoptosis
- permeability role
- vegf
- expression
- increases
- Biochemistry & Molecular Biology
- Biophysics
- Cell Biology
- Preeclampsia
Publication and Content Type
- ref (subject category)
- art (subject category)
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