onr:"swepub:oai:gup.ub.gu.se/320316"
Search: onr:"swepub:oai:gup.ub.gu.se/320316" > Genetic and epigene...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Polli, A. (author)
Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-10-25
- Springer Science and Business Media LLC,2022
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/320316
- https://gup.ub.gu.se/publication/320316URI
- https://doi.org/10.1186/s12967-022-03662-7DOI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening. COMT regulates nociceptive processing and inflammation, key pathophysiological features of Chronic Fatigue Syndrome and Fibromyalgia (CFS/FM). We aimed to determine the interactions between genetic and epigenetic mechanisms regulating COMT and its influence on inflammatory markers and symptoms in patients with CFS/FM. Methods. A case-control study with repeated-measures design was used to reduce the chance of false positive and increase the power of our findings. Fifty-four participants (28 patients with CFS/FM and 26 controls) were assessed twice within 4 days. The assessment included clinical questionnaires, neurophysiological assessment (pain thresholds, temporal summation, and conditioned pain modulation), and blood withdrawal in order to assess rs4818, rs4633, and rs4680 COMT polymorphisms and perform haplotype estimation, DNA methylation in the COMT gene (both MB-COMT and S-COMT promoters), and cytokine expression (TNF-alpha, IFN-gamma, IL-6, and TGF-beta). Results. COMT haplotypes were associated with DNA methylation in the S-COMT promoter, TGF-beta expression, and symptoms. However, this was not specific for one condition. Significant between-group differences were found for increased DNA methylation in the MB-COMT promoter and decreased IFN-gamma expression in patients. Discussion Our results are consistent with basic and clinical research, providing interesting insights into genetic-epigenetic regulatory mechanisms. MB-COMT DNA methylation might be an independent factor contributing to the pathophysiology of CFS/FM. Further research on DNA methylation in complex conditions such as CFS/FM is warranted. We recommend future research to employ a repeated-measure design to control for biomarkers variability and within-subject changes.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- Genetics
- Epigenetics
- DNA methylation
- catechol-O-methyltransferase
- (COMT)
- Inflammation
- Cytokines
- temporal summation
- pain
- cytokine
- blood
- cells
- Research & Experimental Medicine
Added entries (persons, corporate bodies, meetings, titles ...)
- Hendrix, J. (author)
- Ickmans, K. (author)
- Bakusic, J. (author)
- Ghosh, M. (author)
- Monteyne, D. (author)
- Velkeniers, B. (author)
- Bekaert, B. (author)
- Nijs, JoGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology (author)
- Godderis, L. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
Related titles
- In:Journal of Translational Medicine: Springer Science and Business Media LLC20:11479-5876
Internet link
Find in a library
- Journal of Translational Medicine (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Polli, A.
- Hendrix, J.
- Ickmans, K.
- Bakusic, J.
- Ghosh, M.
- Monteyne, D.
- show more...
- Velkeniers, B.
- Bekaert, B.
- Nijs, Jo
- Godderis, L.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- Journal of Trans ...
- By the university
- University of Gothenburg
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
