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Prospective registr...
Prospective registration of symptoms and times to diagnosis in children and adolescents with central nervous system tumors: A study of the Swedish Childhood Cancer Registry
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- Rask, Olof (author)
- Lund University,Lunds universitet,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne,Skåne University Hospital
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- Nilsson, Fredrik (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Lahteenmaki, P. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,University of Turku
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- Ehrstedt, Christoffer (author)
- Uppsala University,Uppsala universitet,Barnonkologisk och neurologisk forskning,Uppsala Univ Childrens Hosp, Uppsala, Sweden
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- Holm, S. (author)
- Karolinska Institute,Karolinska University Hospital
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- Sandström, Per-Erik (author)
- Umeå University,Umeå universitet,Pediatrik,Umeå Univ, Dept Pediat, Umeå, Sweden.
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- Nyman, Per (author)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Univ Hosp Linköping, Ctr Med Imaging & Visualizat CMIV, Linköping, Sweden.,Linköping University Hospital
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- Sabel, Magnus, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg and Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Gothenburg, Sweden.
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- Grillner, P. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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Swedish Childhood, C. N. S. Tumor Workin (author)
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(creator_code:org_t)
- 2022-06-23
- 2022
- English.
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In: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 69:11
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Abstract
Subject headings
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- Background The elapsed time taken to diagnose tumors of the central nervous system in children and adolescents varies widely. The aim of the present study was to investigate such diagnostic time intervals at a national level in Sweden as they correlate with clinical features. Methods Data prospectively accumulated over a 4-year period in the Swedish Childhood Cancer Registry from patients aged 0-18 years were pooled, and diagnostic time intervals were analyzed considering tumor location, tumor type, patient age and sex, initial symptoms, and clinical timelines. All six pediatric oncology centers in Sweden contributed to collection of data. Time points for calculating the total diagnostic interval (TDI) defined as the time from symptom onset to diagnosis were reported in 257 of 319 patients (81%). Results The time from symptom onset to the first healthcare consultation, median 2.6 weeks, did not vary significantly between patients categorized according to tumor type or location. The median TDI was 8.3 weeks for the 4-year study period. Patients with optic pathway glioma (TDI 26.6 weeks), those with tumors of the spinal cord (TDI 25.9 weeks), and those with midline tumors (TDI 24.6 weeks) had the longest lead times. Additionally, older age, too few initial symptoms, and seeking initial redress outside an emergency ward were factors associated with a longer time to diagnosis. Conclusion This study identified several factors associated with delayed diagnosis of central nervous system tumors among Swedish children and adolescents. These novel data ought to help direct future efforts toward clinical improvement.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- adolescent central nervous system
- child
- diagnosis
- tumors
- pediatric brain-tumors
- cns tumors
- survival
- health
- delay
- care
- headsmart
- onset
- Oncology
- Hematology
- Pediatrics
- adolescent central nervous system
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rask, Olof
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Nilsson, Fredrik
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Lahteenmaki, P.
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Ehrstedt, Christ ...
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Holm, S.
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Sandström, Per-E ...
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show more...
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Nyman, Per
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Sabel, Magnus, 1 ...
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Grillner, P.
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Swedish Childhoo ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Pediatric Blood ...
- By the university
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University of Gothenburg
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Umeå University
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Linköping University
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Uppsala University
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Lund University
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Karolinska Institutet