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Short-acting β2 -ag...
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Melén, ErikKarolinska Institutet,Karolinska Institute,Sachs’ Children and Youth Hospital
(author)
Short-acting β2 -agonist use and asthma exacerbations in Swedish children: A SABINA Junior study.
- Article/chapterEnglish2022
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LIBRIS-ID:oai:gup.ub.gu.se/320612
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https://gup.ub.gu.se/publication/320612URI
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https://doi.org/10.1111/pai.13885DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-492866URI
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https://lup.lub.lu.se/record/e5557362-531a-4cd1-be14-de72a46cad55URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151807007URI
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Subject category:art swepub-publicationtype
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In adults and adolescents with asthma, use of ≥3 short-acting β2 -agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.This population-based cohort study utilized linked data from the Swedish national healthcare registries involving patients with asthma (<18years) treated in secondary care between 2006-2015. Exacerbation risk, by baseline SABA collection (0-2 vs. ≥3 canisters, further examined as ordinal/continuous variable) and stratified on comorbid atopic disease (allergic rhinitis, dermatitis and eczema, and food/other allergies), was assessed for 1-year follow-up using negative binomial regression.Of 219,561 patients assessed, 45.4%, 31.7%, and 26.5% of patients aged 0-5, 6-11, and 12-17years, respectively, collected ≥3 SABA canisters during the baseline year (high use). Collection of ≥3 SABA canisters (vs. 0-2) was associated with increased exacerbation risk during follow-up (incidence rate ratios [95% confidence interval]: 1.35 [1.29-1.42], 1.22 [1.15-1.29], and 1.26 [1.19-1.34] for 0-5-, 6-11-, and 12-17-year-olds, respectively); the association persisted with SABA as a continuous variable and was stronger among patients without atopic diseases (32%-44% increased risk versus. 14%-21% for those with atopic disease across groups).High SABA use was associated with increased asthma exacerbation risk in children, particularly in those without comorbid atopic diseases, emphasizing the need for asthma medication reviews and reformative initiatives by caregivers and healthcare providers on SABA use.
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Nwaru, Bright I,1978University of Gothenburg,Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xnwabr
(author)
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Wiklund, FredrikStatisticon(Swepub:lu)med-fwd
(author)
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de Fine Licht, SofieAstraZeneca, Sweden
(author)
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Telg, GunillaAstraZeneca, Sweden
(author)
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Maslova, EkaterinaAstraZeneca, UK
(author)
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van der Valk, Ralf J PAstraZeneca, UK
(author)
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Tran, Trung NAstraZeneca, UK
(author)
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Ekström, MagnusLund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Andfåddhet och kronisk andningssvikt,The Institute for Palliative Care,Lund University Research Groups,Breathlessness and chronic respiratory failure(Swepub:lu)med-mue
(author)
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Janson, ChristerUppsala University,Uppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn
(author)
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Karolinska InstituteSachs’ Children and Youth Hospital
(creator_code:org_t)
Related titles
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In:Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology: Wiley33:111399-30380905-6157
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In:Pediatric Allergy and Immunology: Wiley33:110905-6157
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Melén, Erik
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Nwaru, Bright I, ...
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Wiklund, Fredrik
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de Fine Licht, S ...
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Telg, Gunilla
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Maslova, Ekateri ...
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van der Valk, Ra ...
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Tran, Trung N
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Ekström, Magnus
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Janson, Christer
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