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A pre-specified ana...
A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function.
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Heerspink, Hiddo J L (author)
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Cherney, David (author)
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Postmus, Douwe (author)
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Stefánsson, Bergur V (author)
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Chertow, Glenn M (author)
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Dwyer, Jamie P (author)
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Greene, Tom (author)
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Kosiborod, Mikhail (author)
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Langkilde, Anna Maria (author)
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McMurray, John J V (author)
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Correa-Rotter, Ricardo (author)
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Rossing, Peter (author)
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- Christersson, Christina (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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Toto, Robert D (author)
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Wheeler, David C (author)
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- Swedberg, Karl, 1944 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Held, Claes, 1956- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,kardiologi
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Kidney international. - : Elsevier BV. - 1523-1755 .- 0085-2538. ; 101:1, s. 174-184
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http://www.kidney-in...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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Abstract
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- This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high-risk patients based on having chronic kidney disease (CKD) and substantial albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial that had a median follow-up of 2.4 years. Adults with CKD (urinary albumin-to-creatinine ratio 200-5000 mg/g and estimated glomerular filtration rate 25-75 mL/min/1.73m2) were randomized to dapagliflozin 10 mg/day matched to placebo (2152 individuals each). An abrupt decline in kidney function was defined as a pre-specified endpoint of doubling of serum creatinine between two subsequent study visits. We also assessed a post-hoc analysis of investigator-reported acute kidney injury-related serious adverse events. Doubling of serum creatinine between two subsequent visits (median time-interval 100 days) occurred in 63 (2.9%) and 91 (4.2%) participants in the dapagliflozin and placebo groups, respectively (hazard ratio 0.68 [95% confidence interval 0.49, 0.94]). Accounting for the competing risk of mortality did not alter our findings. There was no heterogeneity in the effect of dapagliflozin on abrupt declines in kidney function based on baseline subgroups. Acute kidney injury-related serious adverse events were not significantly different and occurred in 52 (2.5%) and 69 (3.2%) participants in the dapagliflozin and placebo groups, respectively (0.77 [0.54, 1.10]). Thus, in patients with CKD and substantial albuminuria, dapagliflozin reduced the risk of abrupt declines in kidney function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Adult
- Benzhydryl Compounds
- adverse effects
- Diabetes Mellitus
- Type 2
- complications
- drug therapy
- Glomerular Filtration Rate
- Glucosides
- Humans
- Incidence
- Kidney
- Renal Insufficiency
- Chronic
- complications
- diagnosis
- epidemiology
- Sodium-Glucose Transporter 2 Inhibitors
- adverse effects
- SGLT2 inhibitors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Heerspink, Hiddo ...
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Cherney, David
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Postmus, Douwe
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Stefánsson, Berg ...
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Chertow, Glenn M
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Dwyer, Jamie P
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show more...
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Greene, Tom
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Kosiborod, Mikha ...
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Langkilde, Anna ...
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McMurray, John J ...
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Correa-Rotter, R ...
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Rossing, Peter
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Christersson, Ch ...
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Toto, Robert D
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Wheeler, David C
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Swedberg, Karl, ...
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Held, Claes, 195 ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Kidney internati ...
- By the university
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University of Gothenburg
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Uppsala University