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  • Van der Kolk, W. L.Univ Groningen, Netherlands (author)

Unilateral inguinofemoral lymphadenectomy in patients with early-stage vulvar squamous cell carcinoma and a unilateral metastatic sentinel lymph node is safe

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/320870
  • https://gup.ub.gu.se/publication/320870URI
  • https://doi.org/10.1016/j.ygyno.2022.07.017DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-189488URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • On behalf of all GROINSS-V I and II participants: C.F. Levenback, R.H. Hermans, J. Bouda, A. Sharma, D. Luesley, P. Ellis, D.J. Cruickshank, T.J. Duncan, K. Kieser,C. Palle, N.M. Spirtos, D.M. O'Malley, M.M. Leitao, M. Geller, K. Dhar, V. Asher, D.H. Tobias, C. Borgfeldt, J.S. Lea,M. Lood, J. Bailey, B. Eyjolfsdottir, S. Attard-Montalto, K.S. Tewari, P. Persson, R. Manchanda, P. Jensen, L. Van Le
  • Objective. Optimal management of the contralateral groin in patients with early-stage vulvar squamous cell carcinoma (VSCC) and a metastatic unilateral inguinal sentinel lymph node (SN) is unclear. We analyzed patients who participated in GROINSS-V I or II to determine whether treatment of the contralateral groin can safely be omitted in patients with a unilateral metastatic SN.Methods. We selected the patients with a unilateral metastatic SN from the GROINSS-V I and II databases. We determined the incidence of contralateral additional non-SN metastases in patients with unilateral SN-metastasis who underwent bilateral inguinofemoral lymphadenectomy (IFL). In those who underwent only ipsilateral groin treatment or no further treatment, we determined the incidence of contralateral groin recurrences during follow-up.Results. Of 1912 patients with early-stage VSCC, 366 had a unilateral metastatic SN. Subsequently, 244 had an IFL or no treatment of the contralateral groin. In seven patients (7/244; 2.9% [95% CI: 1.4%-5.8%]) disease was di-agnosed in the contralateral groin: five had contralateral non-SN metastasis at IFL and two developed an isolated contralateral groin recurrence after no further treatment. Five of them had a primary tumor >= 30 mm. Bilateral ra-diotherapy was administered in 122 patients, of whom one (1/122; 0.8% [95% CI: 0.1%-4.5%]) had a contralateral groin recurrence.Conclusion. The risk of contralateral lymph node metastases in patients with early-stage VSCC and a unilateral metastatic SN is low. It appears safe to limit groin treatment to unilateral IFL or inguinofemoral radiotherapy in these cases.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).

Subject headings and genre

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  • Van der Zee, A. G. J.Univ Groningen, Netherlands (author)
  • Brännström, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xbrmat (author)
  • Baldwin, P. J. W.Cambridge Univ Hosp NHS Fdn Trust, England (author)
  • Van Doorn, H. C.Univ Med Ctr Rotterdam, Netherlands,Charles Univ Prague, Czech Republic; Gen Univ Hosp Prague, Czech Republic (author)
  • De Hullu, J. A.Radboud Univ Nijmegen, Netherlands (author)
  • Van der Velden, J.Amsterdam Univ Med Ctr, Netherlands (author)
  • Gaarenstroom, K. N.Leiden Univ, Netherlands (author)
  • Slangen, B. F. M.Maastricht Univ, Netherlands (author)
  • Kjölhede, PrebenLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)prekj14 (author)
  • Brännström, Mats,1958Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xbrmat (author)
  • Vergote, I.Leuven Canc Inst, Belgium (author)
  • Holland, C. M.Manchester Univ NHS Fdn Trust, England (author)
  • Coleman, R.Univ Texas MD Anderson Canc Ctr, TX 77030 USA (author)
  • Van Dorst, E. B. L.Univ Med Ctr Utrecht, Netherlands,Catharina Ziekenhuis Eindhoven, Netherlands (author)
  • Van Driel, W. J.Netherlands Canc Inst, Netherlands (author)
  • Nunns, D.Nottingham Univ Hosp NHS Trust, England (author)
  • Widschwendter, M.Univ Innsbruck, Austria (author)
  • Nugent, D.Leeds Teaching Hosp NHS Trust, England (author)
  • DiSilvestro, P. A.Women & Infants Hosp Rhode Isl, RI 02908 USA,Univ Montreal, Canada (author)
  • Mannel, R. S.Univ Oklahoma, OK USA (author)
  • Tjiong, M. Y.Amsterdam Univ Med Ctr, Netherlands (author)
  • Boll, D. (author)
  • Cibula, D. (author)
  • Covens, A.Univ Toronto, Canada (author)
  • Provencher, D. (author)
  • Runnebaum, I. B.Friedrich Schiller Univ, Germany (author)
  • Monk, B. J.St Josephs Hosp, AZ USA (author)
  • Zanagnolo, V.European Canc Inst, Italy (author)
  • Tamussino, K.Med Univ Graz, Austria (author)
  • Oonk, M. H. M.Univ Groningen, Netherlands (author)
  • Levenback, C. F. (author)
  • Hermans, R. H. (author)
  • Bouda, J. (author)
  • Sharma, A. (author)
  • Luesley, D. (author)
  • Ellis, P. (author)
  • Cruickshank, D. J. (author)
  • Duncan, T. J. (author)
  • Kieser, K. (author)
  • Palle, C. (author)
  • Spirtos, N. M. (author)
  • O'Malley, D. M. (author)
  • Leitao, M. M. (author)
  • Geller, M. (author)
  • Dhar, K. (author)
  • Asher, V. (author)
  • Tobias, D. H. (author)
  • Borgfeldt, C. (author)
  • Lea, J. S. (author)
  • Lood, M. (author)
  • Bailey, J. (author)
  • Eyjolfsdottir, B. (author)
  • Attard-Montalto, S. (author)
  • Tewari, K. S. (author)
  • Persson, P. (author)
  • Manchanda, R. (author)
  • Jensen, P. (author)
  • Van Le, L. (author)
  • Univ Groningen, NetherlandsInstitutionen för kliniska vetenskaper (creator_code:org_t)

Related titles

  • In:Gynecologic Oncology: Elsevier BV167:1, s. 3-100090-82581095-6859

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