Search: onr:"swepub:oai:gup.ub.gu.se/321222" >
Prostate Cancer Scr...
-
Hugosson, Jonas,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
(author)
Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only.
- Article/chapterEnglish2022
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/321222
-
https://gup.ub.gu.se/publication/321222URI
-
https://doi.org/10.1056/NEJMoa2209454DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:151891266URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Screening for prostate cancer is burdened by a high rate of overdiagnosis. The most appropriate algorithm for population-based screening is unknown.We invited 37,887 men who were 50 to 60 years of age to undergo regular prostate-specific antigen (PSA) screening. Participants with a PSA level of 3 ng per milliliter or higher underwent magnetic resonance imaging (MRI) of the prostate; one third of the participants were randomly assigned to a reference group that underwent systematic biopsy as well as targeted biopsy of suspicious lesions shown on MRI. The remaining participants were assigned to the experimental group and underwent MRI-targeted biopsy only. The primary outcome was clinically insignificant prostate cancer, defined as a Gleason score of 3+3. The secondary outcome was clinically significant prostate cancer, defined as a Gleason score of at least 3+4. Safety was also assessed.Of the men who were invited to undergo screening, 17,980 (47%) participated in the trial. A total of 66 of the 11,986 participants in the experimental group (0.6%) received a diagnosis of clinically insignificant prostate cancer, as compared with 72 of 5994 participants (1.2%) in the reference group, a difference of -0.7 percentage points (95% confidence interval [CI], -1.0 to -0.4; relative risk, 0.46; 95% CI, 0.33 to 0.64; P<0.001). The relative risk of clinically significant prostate cancer in the experimental group as compared with the reference group was 0.81 (95% CI, 0.60 to 1.1). Clinically significant cancer that was detected only by systematic biopsy was diagnosed in 10 participants in the reference group; all cases were of intermediate risk and involved mainly low-volume disease that was managed with active surveillance. Serious adverse events were rare (<0.1%) in the two groups.The avoidance of systematic biopsy in favor of MRI-directed targeted biopsy for screening and early detection in persons with elevated PSA levels reduced the risk of overdiagnosis by half at the cost of delaying detection of intermediate-risk tumors in a small proportion of patients. (Funded by Karin and Christer Johansson's Foundation and others; GÖTEBORG-2 ISRCTN Registry number, ISRCTN94604465.).
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Månsson, Marianne,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xmanma
(author)
-
Wallström, JonasGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
(author)
-
Axcrona, Ulrika
(author)
-
Carlsson, Sigrid VGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
(author)
-
Egevad, LarsKarolinska Institutet
(author)
-
Geterud, KjellGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
(author)
-
Khatami, Ali,1975Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xkhaal
(author)
-
Kohestani, KimiaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xkohki
(author)
-
Pihl, Carl GustafGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
(author)
-
Socratous, AndreasGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
(author)
-
Stranne, Johan,1970Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xstraj
(author)
-
Godtman, Rebecka Arnsrud,1981Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xgodre
(author)
-
Hellström, Mikael,1950Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology(Swepub:gu)xhelmi
(author)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för urologi
(creator_code:org_t)
Related titles
-
In:The New England journal of medicine387:23, s. 2126-21371533-4406
Internet link
Find in a library
To the university's database
- By the author/editor
-
Hugosson, Jonas, ...
-
Månsson, Mariann ...
-
Wallström, Jonas
-
Axcrona, Ulrika
-
Carlsson, Sigrid ...
-
Egevad, Lars
-
show more...
-
Geterud, Kjell
-
Khatami, Ali, 19 ...
-
Kohestani, Kimia
-
Pihl, Carl Gusta ...
-
Socratous, Andre ...
-
Stranne, Johan, ...
-
Godtman, Rebecka ...
-
Hellström, Mikae ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
The New England ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet