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Outcomes of Cerebra...
Outcomes of Cerebral Venous Thrombosis due to Vaccine-Induced Immune Thrombotic Thrombocytopenia After the Acute Phase
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van de Munckhof, A. (author)
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- Lindgren, Erik, 1993 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Kleinig, T. J. (author)
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Field, T. S. (author)
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Cordonnier, C. (author)
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Krzywicka, K. (author)
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Poli, S. (author)
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van Kammen, M. S. (author)
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Borhani-Haghighi, A. (author)
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Lemmens, R. (author)
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Scutelnic, A. (author)
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Ciccone, A. (author)
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Gattringer, T. (author)
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Wittstock, M. (author)
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Dizonno, V. (author)
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Devroye, A. (author)
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Elkady, A. (author)
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Gunther, A. (author)
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Cervera, A. (author)
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Mengel, A. (author)
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Chew, B. L. A. (author)
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Buck, B. (author)
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Zanferrari, C. (author)
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Garcia-Esperon, C. (author)
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Jacobi, C. (author)
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Soriano, C. (author)
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Michalski, D. (author)
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Zamani, Z. (author)
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Blacquiere, D. (author)
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Johansson, Elias, 1984 (author)
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Cuadrado-Godia, E. (author)
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Vuillier, F. (author)
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Bode, F. J. (author)
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Caparros, F. (author)
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Maier, F. (author)
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Tsivgoulis, G. (author)
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Katzberg, H. D. (author)
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Duan, J. G. (author)
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Burrow, J. (author)
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Pelz, J. (author)
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Mbroh, J. (author)
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Oen, J. (author)
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Schouten, J. (author)
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Zimmermann, J. (author)
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Ng, K. (author)
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Garambois, K. (author)
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Petruzzellis, M. (author)
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Dias, M. C. (author)
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Ghiasian, M. (author)
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Romoli, M. (author)
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Miranda, M. (author)
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Wronski, M. (author)
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Skjelland, M. (author)
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Almasi-Dooghaee, M. (author)
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Cuisenier, P. (author)
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Murphy, S. (author)
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Timsit, S. (author)
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Coutts, S. B. (author)
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Schonenberger, S. (author)
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Nagel, S. (author)
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Hiltunen, S. (author)
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Chatterton, S. (author)
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Cox, T. (author)
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Bartsch, T. (author)
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Shaygannejad, V. (author)
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Mirzaasgari, Z. (author)
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Middeldorp, S. (author)
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Levi, M. M. (author)
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Hovinga, J. A. K. (author)
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Putaala, J. (author)
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Heldner, M. R. (author)
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Arnold, M. (author)
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de Sousa, D. A. (author)
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Ferro, J. M. (author)
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Coutinho, J. M. (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- English.
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In: Stroke. - : Ovid Technologies (Wolters Kluwer Health). - 0039-2499 .- 1524-4628. ; 53:10, s. 3206-3210
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0-2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization). Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94-194). Two patients died during follow-up (3% [95% CI, 1%-11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%-94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed). Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- hospitalization
- intracranial thrombosis
- mortality
- thrombocytopenia
- vaccination
- venous thrombosis
- sinus thrombosis
- risk
- Neurosciences & Neurology
- Cardiovascular System & Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stroke
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To the university's database
- By the author/editor
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van de Munckhof, ...
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Lindgren, Erik, ...
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Kleinig, T. J.
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Field, T. S.
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Cordonnier, C.
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Krzywicka, K.
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show more...
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Poli, S.
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van Kammen, M. S ...
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Borhani-Haghighi ...
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Lemmens, R.
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Scutelnic, A.
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Ciccone, A.
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Gattringer, T.
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Wittstock, M.
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Dizonno, V.
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Devroye, A.
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Elkady, A.
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Gunther, A.
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Cervera, A.
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Mengel, A.
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Chew, B. L. A.
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Buck, B.
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Zanferrari, C.
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Garcia-Esperon, ...
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Jacobi, C.
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Soriano, C.
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Michalski, D.
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Zamani, Z.
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Blacquiere, D.
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Johansson, Elias ...
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Cuadrado-Godia, ...
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Vuillier, F.
-
Bode, F. J.
-
Caparros, F.
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Maier, F.
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Tsivgoulis, G.
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Katzberg, H. D.
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Duan, J. G.
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Burrow, J.
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Pelz, J.
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Mbroh, J.
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Oen, J.
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Schouten, J.
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Zimmermann, J.
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Ng, K.
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Garambois, K.
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Petruzzellis, M.
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Dias, M. C.
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Ghiasian, M.
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Romoli, M.
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Miranda, M.
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Wronski, M.
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Skjelland, M.
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Almasi-Dooghaee, ...
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Cuisenier, P.
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Murphy, S.
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Timsit, S.
-
Coutts, S. B.
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Schonenberger, S ...
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Nagel, S.
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Hiltunen, S.
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Chatterton, S.
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Cox, T.
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Bartsch, T.
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Shaygannejad, V.
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Mirzaasgari, Z.
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Middeldorp, S.
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Levi, M. M.
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Hovinga, J. A. K ...
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Jood, Katarina, ...
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Tatlisumak, Turg ...
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Putaala, J.
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Heldner, M. R.
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Arnold, M.
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de Sousa, D. A.
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Ferro, J. M.
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Coutinho, J. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Stroke
- By the university
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University of Gothenburg