Search: onr:"swepub:oai:gup.ub.gu.se/321399" >
High-resolution str...
High-resolution structure of a fish aquaporin reveals a novel extracellular fold
-
- Zeng, Jiao (author)
- Universiti Kebangsaan Singapura (NUS),National University of Singapore (NUS),National University of Singapore
-
- Schmitz, Florian (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
- Isaksson, Simon, 1988 (author)
- Chalmers University of Technology
-
show more...
-
- Glas, Jessica (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
- Arbab, Olivia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
- Andersson, Martin, 1974 (author)
- Chalmers University of Technology
-
- Sundell, Kristina, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg
-
- Eriksson, Leif A, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
- Swaminathan, Kunchithapadam (author)
- Universiti Kebangsaan Singapura (NUS),National University of Singapore (NUS),National University of Singapore
-
- Törnroth-Horsefield, Susanna (author)
- Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
-
- Hedfalk, Kristina, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
show less...
-
(creator_code:org_t)
- 2022-10-13
- 2022
- English.
-
In: Life Science Alliance. - : Life Science Alliance, LLC. - 2575-1077. ; 5:12
- Related links:
-
https://research.cha... (primary) (free)
-
show more...
-
http://dx.doi.org/10... (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.2...
-
https://research.cha...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Aquaporins are protein channels embedded in the lipid bilayer in cells from all organisms on earth that are crucial for water homeostasis. In fish, aquaporins are believed to be important for osmoregulation; however, the molecular mechanism behind this is poorly understood. Here, we present the first structural and functional characterization of a fish aquaporin; cpAQP1aa from the fresh water fish climbing perch (Anabas testudineus), a species that is of high osmoregulatory interest because of its ability to spend time in seawater and on land. These studies show that cpAQP1aa is a water-specific aquaporin with a unique fold on the extracellular side that results in a constriction region. Functional analysis combined with molecular dynamic simulations suggests that phosphorylation at two sites causes structural perturbations in this region that may have implications for channel gating from the extracellular side.
Subject headings
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Zeng, Jiao
-
Schmitz, Florian
-
Isaksson, Simon, ...
-
Glas, Jessica
-
Arbab, Olivia
-
Andersson, Marti ...
-
show more...
-
Sundell, Kristin ...
-
Eriksson, Leif A ...
-
Swaminathan, Kun ...
-
Törnroth-Horsefi ...
-
Hedfalk, Kristin ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Theoretical Chem ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Structural Biolo ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biochemistry and ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Biophysics
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Zoology
- Articles in the publication
-
Life Science All ...
- By the university
-
University of Gothenburg
-
Chalmers University of Technology
-
Lund University