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High-resolution str...
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Zeng, JiaoUniversiti Kebangsaan Singapura (NUS),National University of Singapore (NUS),National University of Singapore
(author)
High-resolution structure of a fish aquaporin reveals a novel extracellular fold
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-10-13
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Life Science Alliance, LLC,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/321399
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https://gup.ub.gu.se/publication/321399URI
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https://doi.org/10.26508/lsa.202201491DOI
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https://research.chalmers.se/publication/532679URI
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https://lup.lub.lu.se/record/c1553adb-11f5-4d5e-86ef-6f5bf3dfbfe1URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Aquaporins are protein channels embedded in the lipid bilayer in cells from all organisms on earth that are crucial for water homeostasis. In fish, aquaporins are believed to be important for osmoregulation; however, the molecular mechanism behind this is poorly understood. Here, we present the first structural and functional characterization of a fish aquaporin; cpAQP1aa from the fresh water fish climbing perch (Anabas testudineus), a species that is of high osmoregulatory interest because of its ability to spend time in seawater and on land. These studies show that cpAQP1aa is a water-specific aquaporin with a unique fold on the extracellular side that results in a constriction region. Functional analysis combined with molecular dynamic simulations suggests that phosphorylation at two sites causes structural perturbations in this region that may have implications for channel gating from the extracellular side.
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Schmitz, FlorianGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xschfl
(author)
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Isaksson, Simon,1988Chalmers University of Technology(Swepub:cth)isakssos
(author)
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Glas, JessicaGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xgljes
(author)
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Arbab, OliviaGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
(author)
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Andersson, Martin,1974Chalmers University of Technology(Swepub:cth)martina
(author)
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Sundell, Kristina,1959Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences,University of Gothenburg(Swepub:gu)xskris
(author)
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Eriksson, Leif A,1964Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xeleif
(author)
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Swaminathan, KunchithapadamUniversiti Kebangsaan Singapura (NUS),National University of Singapore (NUS),National University of Singapore
(author)
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Törnroth-Horsefield, SusannaLund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)bioc-sst
(author)
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Hedfalk, Kristina,1969Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xhedkr
(author)
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Universiti Kebangsaan Singapura (NUS)National University of Singapore
(creator_code:org_t)
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In:Life Science Alliance: Life Science Alliance, LLC5:122575-1077
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