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Risk to human healt...
Risk to human health related to the presence of perfluoroalkyl substances in food.
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Schrenk, Dieter (author)
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Bignami, Margherita (author)
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Bodin, Laurent (author)
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Chipman, James Kevin (author)
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Del Mazo, Jesús (author)
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Grasl-Kraupp, Bettina (author)
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Hogstrand, Christer (author)
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Hoogenboom, Laurentius Ron (author)
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Leblanc, Jean-Charles (author)
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Nebbia, Carlo Stefano (author)
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Nielsen, Elsa (author)
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Ntzani, Evangelia (author)
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Petersen, Annette (author)
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- Sand, Salomon (author)
- Karolinska Institutet
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Vleminckx, Christiane (author)
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Wallace, Heather (author)
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- Barregård, Lars, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Ceccatelli, Sandra (author)
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Cravedi, Jean-Pierre (author)
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Halldorsson, Thorhallur Ingi (author)
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Haug, Line Småstuen (author)
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Johansson, Niklas (author)
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Knutsen, Helle Katrine (author)
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Rose, Martin (author)
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Roudot, Alain-Claude (author)
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Van Loveren, Henk (author)
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Vollmer, Günter (author)
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Mackay, Karen (author)
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Riolo, Francesca (author)
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Schwerdtle, Tanja (author)
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(creator_code:org_t)
- Wiley, 2020
- 2020
- English.
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In: EFSA journal. European Food Safety Authority. - : Wiley. - 1831-4732. ; 18:9
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https://efsa.onlinel...
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
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- The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluoroalkyl substances (PFASs) in food. Based on several similar effects in animals, toxicokinetics and observed concentrations in human blood, the CONTAM Paneldecided to perform the assessment for the sum of four PFASs: PFOA, PFNA, PFHxS and PFOS. These made up half of the lower bound (LB) exposure to those PFASs with available occurrence data, the remaining contribution being primarily from PFASs with short half-lives. Equal potencies were assumed for the four PFASs included in the assessment. The mean LB exposure in adolescents and adult age groups ranged from 3 to 22, the 95th percentile from 9 to 70 ng/kg body weight (bw) per week. Toddlers and 'other children' showed a twofold higher exposure. Upper bound exposure was 4- to 49-fold higher than LB levels, but the latter were considered more reliable. 'Fish meat', 'Fruit and fruit products' and 'Eggs and egg products' contributed most to the exposure. Based on available studies in animals and humans, effects on the immune system were considered the most critical for the risk assessment. From a human study, a lowest BMDL 10 of 17.5 ng/mL for the sum of the four PFASs in serum was identified for 1-year-old children. Using PBPK modelling, this serum level of 17.5 ng/mL in children was estimated to correspond to long-term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake (TWI) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panelconcluded that parts of the European population exceed this TWI, which is of concern.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schrenk, Dieter
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Bignami, Margher ...
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Bodin, Laurent
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Chipman, James K ...
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Del Mazo, Jesús
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Grasl-Kraupp, Be ...
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show more...
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Hogstrand, Chris ...
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Hoogenboom, Laur ...
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Leblanc, Jean-Ch ...
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Nebbia, Carlo St ...
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Nielsen, Elsa
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Ntzani, Evangeli ...
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Petersen, Annett ...
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Sand, Salomon
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Vleminckx, Chris ...
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Wallace, Heather
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Barregård, Lars, ...
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Ceccatelli, Sand ...
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Cravedi, Jean-Pi ...
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Halldorsson, Tho ...
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Haug, Line Småst ...
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Johansson, Nikla ...
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Knutsen, Helle K ...
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Rose, Martin
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Roudot, Alain-Cl ...
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Van Loveren, Hen ...
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Vollmer, Günter
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Mackay, Karen
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Riolo, Francesca
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Schwerdtle, Tanj ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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EFSA journal. Eu ...
- By the university
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University of Gothenburg
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Karolinska Institutet