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Human intracardiac ...
Human intracardiac SSEA4+CD34 cells show features of cycling, immature cardiomyocytes and are distinct from Side Population and C-kit+CD45- cells
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- Sandstedt, Mikael, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Clinical Chemistry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Vukusic, Kristina, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Clinical Chemistry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Ulfenborg, Benjamin, 1985- (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translationell bioinformatik, Translational Bioinformatics
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- Jonsson, Marianne, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Clinical Chemistry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Mattsson Hultén, Lillemor, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Clinical Chemistry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden ; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Universityof Gothenburg, Sweden
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- Dellgren, Göran, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Universityof Gothenburg, Sweden ; Department of Cardiothoracic Surgery, Region Västra Götaland, Sahlgrenska University Hospital, University of Gothenburg, Sweden
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- Jeppsson, Anders, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Universityof Gothenburg, Sweden ; Department of Cardiothoracic Surgery, Region Västra Götaland, Sahlgrenska University Hospital, University of Gothenburg, Sweden
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- Synnergren, Jane (author)
- Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translationell bioinformatik, Translational Bioinformatics
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- Sandstedt, Joakim (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden ; Department of Clinical Chemistry, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
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(creator_code:org_t)
- 2022-06-16
- 2022
- English.
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 17:6 June
- Related links:
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https://his.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Cardiomyocyte proliferation has emerged as the main source of new cardiomyocytes in the adult. Progenitor cell populations may on the other hand contribute to the renewal of other cell types, including endothelial and smooth muscle cells. The phenotypes of immature cell populations in the adult human heart have not been extensively explored. We therefore investigated whether SSEA4+CD34- cells might constitute immature cycling cardiomyocytes in the adult failing and non-failing human heart. The phenotypes of Side Population (SP) and C-kit+CD45- progenitor cells were also analyzed. Biopsies from the four heart chambers were obtained from patients with end-stage heart failure as well as organ donors without chronic heart failure. Freshly dissociated cells underwent flow cytometric analysis and sorting. SSEA4+CD34- cells expressed high levels of cardiomyocyte, stem cell and proliferation markers. This pattern resembles that of cycling, immature, cardiomyocytes, which may be important in endogenous cardiac regeneration. SSEA4+CD34- cells isolated from failing hearts tended to express lower levels of cardiomyocyte markers as well as higher levels of stem cell markers. C-kit+CD45- and SP CD45- cells expressed high levels of endothelial and stem cell markers–corresponding to endothelial progenitor cells involved in endothelial renewal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- CD34 antigen
- receptor type tyrosine protein phosphatase C
- stage specific embryo antigen 4
- stem cell factor
- stem cell factor receptor
- Article
- cardiac muscle cell
- cell isolation
- cell maturation
- cell population
- cell proliferation
- cell selection
- cell self-renewal
- controlled study
- endothelial progenitor cell
- flow cytometry
- human
- human cell
- phenotype
- protein expression
- signal transduction
- cell culture
- cell differentiation
- heart failure
- metabolism
- physiology
- Antigens
- CD34
- Cells
- Cultured
- Humans
- Myocytes
- Cardiac
- Proto-Oncogene Proteins c-kit
- Bioinformatik
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sandstedt, Mikae ...
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Vukusic, Kristin ...
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Ulfenborg, Benja ...
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Jonsson, Mariann ...
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Mattsson Hultén, ...
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Dellgren, Göran, ...
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Jeppsson, Anders ...
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Synnergren, Jane
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Sandstedt, Joaki ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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PLoS ONE
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University of Gothenburg
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University of Skövde