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Investigating the u...
Investigating the use of plasma pTau181 in retired contact sports athletes
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Vasilevskaya, A. (author)
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Taghdiri, F. (author)
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Multani, N. (author)
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Ozzoude, M. (author)
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Tarazi, A. (author)
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Khodadadi, M. (author)
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Wennberg, R. (author)
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Rusjan, P. (author)
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Houle, S. (author)
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Green, R. (author)
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Colella, B. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Karikari, Thomas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Mikulis, D. (author)
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Hazrati, L. N. (author)
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Kovacs, G. G. (author)
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Davis, K. D. (author)
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Tator, C. (author)
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Tartaglia, M. C. (author)
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(creator_code:org_t)
- 2022-06-25
- 2022
- English.
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In: Journal of Neurology. - : Springer Science and Business Media LLC. - 0340-5354 .- 1432-1459. ; 269, s. 5582-5595
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Abstract
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- Background: Considering the wide range of outcomes following sport-related concussions, biomarkers are needed to detect underlying pathological changes. The objective was to analyze the use of plasma phosphorylated tau 181 (pTau181) as a non-invasive measure of underlying brain changes in a cohort of retired contact sports athletes at risk of neurodegeneration. Methods: Fifty-four retired contact sport athletes and 27 healthy controls whose blood plasma was analyzed for pTau181 were included. A portion (N = 21) of retired athletes had a 2-years follow-up visit. All participants had completed a neuropsychological battery and MRI imaging. Results: Plasma pTau181 was significantly higher in retired athletes compared to healthy controls (8.94 ± 5.08pg/mL vs. 6.00 ± 2.53pg/mL, respectively; 95% BCa CI 1.38–4.62; p = 0.02); and was significantly associated with fornix fractional anisotropy values only in the athletes group (β = − 0.002; 95% BCa CI − 0.003 to − 0.001; p = 0.002). When the retired athletes cohort was divided into high vs. normal pTau181 groups, the corpus callosum (CC) volume and white-matter integrity was significantly lower in high pTau181 compared to older healthy controls (CC volume: 1.57 ± 0.19 vs. 2.02 ± 0.32, p = 0.002; CC medial diffusivity: 0.96 ± 0.04 × 10–3 mm2/s vs. 0.90 ± 0.03 × 10–3 mm2/s, p = 0.003; CC axial diffusivity: 1.49 ± 0.04 × 10–3 mm2/s vs. 1.41 ± 0.02 × 10–3 mm2/s, p < 0.001, respectively). Conclusions: Although high plasma pTau181 levels were associated with abnormalities in CC and fornix, baseline pTau181 did not predict longitudinal changes in regional brain volumes or white-matter integrity in the athletes. pTau181 may be useful for identifying those with brain abnormalities related to repeated concussion but not for predicting progression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Athletes
- Chronic traumatic encephalopathy
- Concussion
- CTE
- Neurodegeneration
- Plasma
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vasilevskaya, A.
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Taghdiri, F.
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Multani, N.
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Ozzoude, M.
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Tarazi, A.
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Khodadadi, M.
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show more...
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Wennberg, R.
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Rusjan, P.
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Houle, S.
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Green, R.
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Colella, B.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Karikari, Thomas
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Mikulis, D.
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Hazrati, L. N.
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Kovacs, G. G.
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Davis, K. D.
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Tator, C.
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Tartaglia, M. C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg