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Modified ent-Abieta...
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
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- Kalenga, T. M. (author)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania;Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, Tanzania
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- Mollel, J. T. (author)
- Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania;Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden
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- Said, Joanna (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden
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- Orthaber, Andreas, 1979- (author)
- Uppsala universitet,Syntetisk molekylär kemi
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- Ward, J. S. (author)
- University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland
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- Atilaw, Yoseph (author)
- Uppsala universitet,Organisk kemi
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- Umereweneza, Daniel (author)
- Uppsala universitet,Organisk kemi,Department of Chemistry, College of Science and Technology, University of Rwanda, P.O Box 3900, Kigali, Rwanda
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- Ndoile, M. M. (author)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
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- Munissi, J. J. E. (author)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
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- Rissanen, K. (author)
- University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland
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- Trybala, Edward, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden
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- Bergström, Tomas, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden
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- Nyandoro, S. S. (author)
- Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania
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- Erdélyi, Máté, 1975- (author)
- Uppsala universitet,Organisk kemi
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Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, PO. Box 35061, Dar es Salaam, Tanzania;Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, Tanzania Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania;Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden (creator_code:org_t)
- 2022-09-08
- 2022
- English.
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In: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 85:9, s. 2135-2141
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and fi-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 mu g/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 mu g/ mL. The isolated compounds 1-3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at >= 100 mu M.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- beta-amyrin
- lactones
- roots
- Plant Sciences
- Pharmacology & Pharmacy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kalenga, T. M.
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Mollel, J. T.
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Said, Joanna
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Orthaber, Andrea ...
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Ward, J. S.
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Atilaw, Yoseph
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show more...
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Umereweneza, Dan ...
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Ndoile, M. M.
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Munissi, J. J. E ...
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Rissanen, K.
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Trybala, Edward, ...
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Bergström, Tomas ...
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Nyandoro, S. S.
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Erdélyi, Máté, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Organic Chemistr ...
- Articles in the publication
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Journal of Natur ...
- By the university
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University of Gothenburg
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Uppsala University