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  • Kalenga, T. M.Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania;Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, Tanzania (author)

Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-09-08
  • American Chemical Society (ACS),2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/322278
  • https://gup.ub.gu.se/publication/322278URI
  • https://doi.org/10.1021/acs.jnatprod.2c00147DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486554URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and fi-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 mu g/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 mu g/ mL. The isolated compounds 1-3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at >= 100 mu M.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mollel, J. T.Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania;Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden (author)
  • Said, JoannaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden(Swepub:gu)xsaijo (author)
  • Orthaber, Andreas,1979-Uppsala universitet,Syntetisk molekylär kemi(Swepub:uu)ortan368 (author)
  • Ward, J. S.University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland (author)
  • Atilaw, YosephUppsala universitet,Organisk kemi(Swepub:uu)yosat333 (author)
  • Umereweneza, DanielUppsala universitet,Organisk kemi,Department of Chemistry, College of Science and Technology, University of Rwanda, P.O Box 3900, Kigali, Rwanda(Swepub:uu)danum412 (author)
  • Ndoile, M. M.Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania (author)
  • Munissi, J. J. E.Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania (author)
  • Rissanen, K.University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland (author)
  • Trybala, Edward,1955Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden(Swepub:gu)xtryed (author)
  • Bergström, Tomas,1950Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden(Swepub:gu)xberto (author)
  • Nyandoro, S. S.Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania (author)
  • Erdélyi, Máté,1975-Uppsala universitet,Organisk kemi(Swepub:uu)mateerde (author)
  • Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania;Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, TanzaniaInstitute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania;Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden (creator_code:org_t)

Related titles

  • In:Journal of Natural Products: American Chemical Society (ACS)85:9, s. 2135-21410163-38641520-6025

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