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- Wang, Y. F. (author)
Cerebellar irradiation does not cause hyperactivity, fear, and anxiety-related disorders in the juvenile rat brain
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-11-15
- Springer Science and Business Media LLC,2022
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- LIBRIS-ID:oai:gup.ub.gu.se/322330
- https://gup.ub.gu.se/publication/322330URI
- https://doi.org/10.1186/s41747-022-00307-8DOI
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- Language:English
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- Background The cerebellum is involved in hyperactivity, fear, and anxiety disorders that could be induced by whole-brain irradiation (WBI). However, whether cerebellar irradiation alone (CIA) could induce these disorders is unknown. We investigated the effect of CIA in an animal model. Methods Eleven-day-old rat pups underwent a single 3-Gy dose of either WBI (n = 28) or CIA (n = 20), while 34 rat pups were sham-irradiated (controls). Cell death was evaluated in the subgranular zone of the hippocampus by counting pyknotic cells after haematoxylin/eosin staining at 6 h after irradiation for 10, 8, and 9 pups, respectively. Behavioural changes were evaluated via open-field test at 6 weeks for 18, 12, and 25 pups, respectively. Unpaired two-tailed t-test and one-way and two-way repeated ANOVA were used. Results Massive cell death in cerebellar external granular layer was detected at 6 h after CIA (1,419 +/- 211 mm, mean +/- S.E.M. versus controls (68 +/- 12 mm) (p < 0.001)), while no significant difference between CIA (1,419 +/- 211 mm) versus WBI (1,433 +/- 107 mm) (p = 0.955) was found. At open-field behavioural test, running distance, activity, wall distance, middle zone visit times, and duration were higher for WBI versus controls (p < 0.010), but no difference between CIA and controls was found (p > 0.05). Conclusions Although the cerebellum is involved in hyperactivity, fear, and anxiety disorders, CIA did not induce these disorders, indicating that WBI-induced cerebellar injury does not directly cause these behavioural abnormalities after WBI. Thus, targeting the cerebellum alone may not be enough to rescue or reduce these behavioural abnormalities after WBI.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Anxiety
- Cerebellum
- Models (animal)
- Hyperactivity
- Radiotherapy
- outcomes
- tumors
- connectivity
- radiotherapy
- mechanisms
- children
- cortex
- Radiology
- Nuclear Medicine & Medical Imaging
Added entries (persons, corporate bodies, meetings, titles ...)
- Xie, CuicuiGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xxiecu (author)
- Xu, Y. R. (author)
- Zhang, Y. D. (author)
- Zhu, Changlian,1964Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xzhuch (author)
- Zhou, K. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
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- In:European Radiology Experimental: Springer Science and Business Media LLC6:12509-9280
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