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  • Ørnbjerg, L. M.Copenhagen University Hospital (author)

Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/323424
  • https://gup.ub.gu.se/publication/323424URI
  • https://doi.org/10.1016/j.semarthrit.2022.152081DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150590479URI
  • https://lup.lub.lu.se/record/76c17354-3c65-4128-a799-1470441ed8a1URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Methods: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data. Results: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97–0.98), men vs. women: 1.88 (1.60–2.22), current vs. non-smoking: 0.76 (0.63–0.91), HLA-B27 positive vs. negative: 1.51 (1.20–1.91), TNF start year 2015–2018 vs. 2009–2014: 1.24 (1.06–1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25–1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58–1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99–1.00) and 0.99 (0.99–1.99), respectively Conclusion: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.

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  • Linde, L. (author)
  • Georgiadis, S.Copenhagen University Hospital (author)
  • Rasmussen, S. H.Copenhagen University Hospital,Portuguese Institute of Rheumatology,NOVA University Lisbon (author)
  • Lindström, UlfUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:gu)xlulfn (author)
  • Askling, J.Karolinska Institute,Karolinska Institutet (author)
  • Michelsen, B.Sørlandet Hospital,Copenhagen University Hospital,Diakonhjemmet Hospital (author)
  • Giuseppe, D. D.Karolinska Institute,Karolinska Institutet (author)
  • Wallman, Johan K.Lund University,Lunds universitet,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jnk (author)
  • Pavelka, K.Charles University in Prague,Institute of Rheumatology, Prague (author)
  • Závada, J.Charles University in Prague,Institute of Rheumatology, Prague (author)
  • Nissen, M. J.Geneva University Hospital (author)
  • Jones, G. T.University of Aberdeen (author)
  • Relas, H.Helsinki University Central Hospital (author)
  • Pirilä, L.University of Turku,Turku University Hospital (author)
  • Tomšič, M.University Medical Centre Ljubljana,University of Ljubljana (author)
  • Rotar, Z.University Medical Centre Ljubljana,University of Ljubljana (author)
  • Geirsson, A. J.National University Hospital of Iceland (author)
  • Gudbjornsson, B.National University Hospital of Iceland,University of Iceland (author)
  • Kristianslund, E. K.Diakonhjemmet Hospital (author)
  • van sder Horst-Bruinsma, I.Radboud University Medical Center (author)
  • Loft, A. G.Aarhus University,Aarhus University Hospital (author)
  • Laas, K.East Tallinn Central Hospital (author)
  • Iannone, F.University of Bari Aldo Moro (author)
  • Corrado, A.University of Foggia (author)
  • Ciurea, A.University Hospital of Zurich (author)
  • Santos, M. J.Hospital Garcia de Orta (author)
  • Santos, H. (author)
  • Codreanu, C.Carol Davila University of Medicine and Pharmacy (author)
  • Akkoc, N.Celal Bayar University Hospital (author)
  • Gunduz, O. S.Celal Bayar University Hospital (author)
  • Glintborg, B.University of Copenhagen,Copenhagen University Hospital (author)
  • Østergaard, M.University of Copenhagen,Copenhagen University Hospital (author)
  • Hetland, M. L.University of Copenhagen,Copenhagen University Hospital (author)
  • Copenhagen University HospitalPortuguese Institute of Rheumatology (creator_code:org_t)

Related titles

  • In:Seminars in Arthritis and Rheumatism: Elsevier BV560049-01721532-866X

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