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Brachytherapy and o...
Brachytherapy and osteoradionecrosis in patients with base of tongue cancer
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- Danielsson, D. (author)
- Karolinska Institutet
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- Hagel, E. (author)
- Karolinska Institutet
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- Dybeck-Udd, S. (author)
- Department of Oral and Maxillofacial Surgery, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Oral & Maxillofacial Surg, Stockholm, Sweden.
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- Sjöström, Mats (author)
- Umeå University,Umeå universitet,Institutionen för odontologi,Oral and Maxillofacial Surgery, Umeå University Hospital, Umeå, Sweden,Umeå Univ, Dept Odontol, Umeå, Sweden.;Umeå Univ Hosp, Oral & Maxillofacial Surg, Umeå, Sweden.
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- Kjeller, Göran (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Sweden,Univ Gothenburg, Inst Odontol, Dept Oral & Maxillofacial Surg, Sahlgrenska Acad, Gothenburg, Sweden.
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- Bengtsson, Martin (author)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Abtahi, Jahan (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Käkkliniken US,Linköping Univ Hosp, Dept Oral & Maxillofacial Surg, Linköping, Sweden.,Linköping University Hospital
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- Von Beckerath, Mathias, 1966- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Örebro University, Örebro, Sweden;Medical Unit Head and Neck, Lung and Skin Cancer, Karolinska University Hospital, Stockholm, Sweden,Örebro Univ, Dept Med Sci, Örebro, Sweden.;Karolinska Univ Hosp, Med Unit Head & Neck Lung & Skin Canc, Stockholm, Sweden.
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- Thor, Andreas (author)
- Uppsala University,Uppsala universitet,Odontologi & Maxillofacial kirurgi
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- Halle, M. (author)
- Karolinska Institutet
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- Friesland, S. (author)
- Karolinska Institutet
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- Mercke, C. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Westermark, A. (author)
- Department of Surgery, Åland Central Hospital, Mariehamn, Finland,Aland Cent Hosp, Dept Surg, Mariehamn, Finland.
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- Högmo, A. (author)
- Karolinska Institutet
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- Munck-Wikland, E. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2023-01-03
- 2023
- English.
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In: Acta Oto-Laryngologica. - : Informa UK Limited. - 0001-6489 .- 1651-2251. ; 143:1, s. 77-84
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Abstract
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- Background: Base of tongue cancer incidence and patient survival is increasing why treatment sequelae becomes exceedingly important. Osteoradionecrosis (ORN) is a late adverse effect of radiotherapy and brachytherapy (BT) could be a risk factor. Brachytherapy is used in three out of six health care regions in Sweden. Aims: Investigate if patients treated in regions using BT show an increased risk for ORN and whether brachytherapy has any impact on overall survival. Material and Methods: We used data from the Swedish Head and Neck Cancer Register between 2008–2014. Due to the nonrandomized nature of the study and possible selection bias we compared the risk for ORN in brachy vs non-brachy regions. Results: Fifty out of 505 patients (9.9%) developed ORN; eight of these were treated in nonbrachy regions (16%), while 42 (84%) were treated in brachy regions. Neither age, sex, TNM-classification/stage, p16, smoking, neck dissection, or chemotherapy differed between ORN and no-ORN patients. The risk for ORN was significantly higher for patients treated in brachy regions compared to non-brachy regions (HR = 2,63, p =.012), whereas overall survival did not differ (HR = 0.95, p =.782). Conclusions and Significance: Brachytherapy ought to be used cautiously for selected patients or within prospective randomized studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- base of tongue cancer
- Brachytherapy
- head and neck cancer
- osteoradionecrosis
- sequelae
- Brachytherapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Danielsson, D.
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Hagel, E.
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Dybeck-Udd, S.
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Sjöström, Mats
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Kjeller, Göran
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Bengtsson, Marti ...
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Abtahi, Jahan
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Von Beckerath, M ...
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Thor, Andreas
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Halle, M.
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Friesland, S.
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Mercke, C.
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Westermark, A.
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Högmo, A.
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Munck-Wikland, E ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
- Articles in the publication
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Acta Oto-Laryngo ...
- By the university
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University of Gothenburg
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Örebro University
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Umeå University
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Linköping University
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Uppsala University
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Lund University
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Karolinska Institutet
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