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Quantitative relati...
Quantitative relationships of perfluoroalkyl acids in drinking water associated with serum concentrations above background in adults living near contamination hotspots in Sweden
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- Johanson, G. (author)
- Karolinska Institutet,Swedish University of Agricultural Sciences, Uppsala,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Karolinska Institute
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- Gyllenhammar, I. (author)
- Swedish University of Agricultural Sciences, Uppsala,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,National Food Agency
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- Ekstrand, Carl (author)
- Swedish University of Agricultural Sciences, Uppsala,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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- Pyko, A. (author)
- Karolinska Institutet,Karolinska Institute,Center for Occupational and Environmental Health, Stockholm
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- Xu, Yiyi (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy
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- Li, Ying (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy
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- Norström, K. (author)
- Swedish Environmental Protection Agency
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- Lilja, K. (author)
- Swedish Environmental Protection Agency
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- Lindh, Christian (author)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Benskin, Jonathan P. (author)
- Stockholm University,Stockholms universitet,Institutionen för miljövetenskap
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- Georgelis, A. (author)
- Karolinska Institutet,Karolinska Institute,Center for Occupational and Environmental Health, Stockholm
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- Forsell, Karl (author)
- Occupational and Environmental Medicine, Norrland University Hospital, Umeå, Sweden
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- Jakobsson, Kristina (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Glynn, A. (author)
- Swedish University of Agricultural Sciences, Uppsala,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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- Vogs, C. (author)
- Karolinska Institutet,Swedish University of Agricultural Sciences, Uppsala,Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health
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(creator_code:org_t)
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- Elsevier BV, 2023
- 2023
- English.
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In: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 219
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Abstract
Subject headings
Close
- Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quantitative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PFPeA, PFHxA, PFHpA, and PFBS) and long-chained PFAAs (PFOA, PFNA, PFDA, PFHxS and PFOS) were measured in DW and serum. We matched DW and serum concentrations for a total of 398 subjects living or working in areas receiving contaminated DW and in one non-contaminated area. Thereafter, linear regression analysis with and without adjustments for co-variates was conducted. This enabled to derive (i) serum concentrations at background exposure (CB) from sources other than local DW exposure (i.e. food, dust and textiles) at 0 ng/L DW concentration, (ii) population-mean PFAA serum:water ratios (SWR) and (iii) PFAA concentrations in DW causing observable elevated serum PFAA concentrations above background variability. Median concentrations of the sum of nine PFAAs ranged between 2.8 and 1790 ng/L in DW and between 7.6 and 96.9 ng/mL in serum. DW concentration was the strongest predictor, resulting in similar unadjusted and adjusted regression coefficients. Mean CB ranged from <0.1 (PFPeA, PFHpA, PFBS) to 5.1 ng/mL (PFOS). Serum concentrations increased significantly with increasing DW concentrations for all PFAAs except for PFPeA with SWRs ranging from <10 (PFHxA, PFHpA and PFBS) to 111 (PFHxS). Observed elevated serum concentrations above background variability were reached at DW concentrations between 24 (PFOA) and 357 ng/L (PFHxA). The unadjusted linear regression predictions agreed well with serum concentrations previously reported in various populations exposed to low and high DW levels of PFOA, PFHxS and PFOS. The quantitative relationships derived herein should be helpful to translate PFAA concentrations in DW to concentrations in serum at the population level.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
Keyword
- Bioaccumulation
- Human biomonitoring
- PFAS
- Risk assessment
- Tap water
- Toxicokinetics
- Bioaccumulation
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Johanson, G.
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Gyllenhammar, I.
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Ekstrand, Carl
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Pyko, A.
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Xu, Yiyi
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Li, Ying
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Norström, K.
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Lilja, K.
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Lindh, Christian
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Benskin, Jonatha ...
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Georgelis, A.
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Forsell, Karl
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Jakobsson, Krist ...
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Glynn, A.
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Vogs, C.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
- Articles in the publication
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Environmental Re ...
- By the university
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University of Gothenburg
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Swedish University of Agricultural Sciences
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Umeå University
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Stockholm University
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Lund University
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Karolinska Institutet