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Long non-coding RNA...
Long non-coding RNAs: definitions, functions, challenges and recommendations
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Mattick, J. S. (author)
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Amaral, P. P. (author)
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Carninci, P. (author)
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Carpenter, S. (author)
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Chang, H. Y. (author)
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Chen, L. L. (author)
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Chen, R. S. (author)
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Dean, C. (author)
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Dinger, M. E. (author)
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Fitzgerald, K. A. (author)
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Gingeras, T. R. (author)
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Guttman, M. (author)
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Hirose, T. (author)
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Huarte, M. (author)
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Johnson, R. (author)
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- Kanduri, Chandrasekhar, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Kapranov, P. (author)
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Lawrence, J. B. (author)
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Lee, J. T. (author)
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Mendell, J. T. (author)
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Mercer, T. R. (author)
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Moore, K. J. (author)
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Nakagawa, S. (author)
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Rinn, J. L. (author)
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Spector, D. L. (author)
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Ulitsky, I. (author)
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Wan, Y. (author)
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Wilusz, J. E. (author)
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Wu, M. (author)
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(creator_code:org_t)
- 2023-01-03
- 2023
- English.
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In: Nature Reviews Molecular Cell Biology. - : Springer Science and Business Media LLC. - 1471-0072 .- 1471-0080. ; 24:6, s. 430-447
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Abstract
Subject headings
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- Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns. The various functions of lncRNAs and their many isoforms and interleaved relationships with other genes make lncRNA classification and annotation difficult. Most lncRNAs evolve more rapidly than protein-coding sequences, are cell type specific and regulate many aspects of cell differentiation and development and other physiological processes. Many lncRNAs associate with chromatin-modifying complexes, are transcribed from enhancers and nucleate phase separation of nuclear condensates and domains, indicating an intimate link between lncRNA expression and the spatial control of gene expression during development. lncRNAs also have important roles in the cytoplasm and beyond, including in the regulation of translation, metabolism and signalling. lncRNAs often have a modular structure and are rich in repeats, which are increasingly being shown to be relevant to their function. In this Consensus Statement, we address the definition and nomenclature of lncRNAs and their conservation, expression, phenotypic visibility, structure and functions. We also discuss research challenges and provide recommendations to advance the understanding of the roles of lncRNAs in development, cell biology and disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- genome-wide analysis
- messenger-rna
- phase-separation
- transcriptional
- regulation
- antisense rna
- gene-expression
- xist rna
- transposable
- elements
- accessible chromatin
- dosage compensation
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Mattick, J. S.
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Amaral, P. P.
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Carninci, P.
-
Carpenter, S.
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Chang, H. Y.
-
Chen, L. L.
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show more...
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Chen, R. S.
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Dean, C.
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Dinger, M. E.
-
Fitzgerald, K. A ...
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Gingeras, T. R.
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Guttman, M.
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Hirose, T.
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Huarte, M.
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Johnson, R.
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Kanduri, Chandra ...
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Kapranov, P.
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Lawrence, J. B.
-
Lee, J. T.
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Mendell, J. T.
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Mercer, T. R.
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Moore, K. J.
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Nakagawa, S.
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Rinn, J. L.
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Spector, D. L.
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Ulitsky, I.
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Wan, Y.
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Wilusz, J. E.
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Wu, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Reviews M ...
- By the university
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University of Gothenburg