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International Valid...
International Validation of the EORTC QLQ-ANL27, a Field Study to Test the Anal Cancer–Specific Health-Related Quality of Life Questionnaire
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Sodergren, S. C. (author)
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Johnson, C. D. (author)
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Gilbert, A. (author)
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Darlington, A. S. (author)
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Cocks, K. (author)
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Guren, M. G. (author)
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Rivin del Campo, E. (author)
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Brannan, C. (author)
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Christensen, P. (author)
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Chu, W. (author)
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Chung, H. (author)
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Dennis, K. (author)
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Desideri, I. (author)
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Gilbert, D. C. (author)
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Glynne-Jones, R. (author)
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Jefford, M. (author)
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- Johansson, Mia, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Johnsson, A. (author)
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Juul, T. (author)
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Kardamakis, D. (author)
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Lai-Kwon, J. (author)
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McFarlane, V. (author)
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Miguel, I. M. C. (author)
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Nugent, K. (author)
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Peters, F. (author)
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Riechelmann, R. P. (author)
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Turhal, N. S. (author)
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Wong, S. (author)
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Vassiliou, V. (author)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: International Journal of Radiation Oncology Biology Physics. - : Elsevier BV. - 0360-3016. ; 115:5, s. 1155-1164
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https://doi.org/10.1...
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Abstract
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- Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. Methods and Materials: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. Results: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. Conclusions: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Sodergren, S. C.
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Johnson, C. D.
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Gilbert, A.
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Darlington, A. S ...
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Cocks, K.
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Guren, M. G.
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show more...
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Rivin del Campo, ...
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Brannan, C.
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Christensen, P.
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Chu, W.
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Chung, H.
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Dennis, K.
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Desideri, I.
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Gilbert, D. C.
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Glynne-Jones, R.
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Jefford, M.
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Johansson, Mia, ...
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Johnsson, A.
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Juul, T.
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Kardamakis, D.
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Lai-Kwon, J.
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McFarlane, V.
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Miguel, I. M. C.
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Nugent, K.
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Peters, F.
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Riechelmann, R. ...
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Turhal, N. S.
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Wong, S.
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Vassiliou, V.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
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University of Gothenburg