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Genetic mechanisms ...
Genetic mechanisms of 184 neuro-related proteins in human plasma.
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Repetto, Linda (author)
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Chen, Jiantao (author)
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Yang, Zhijian (author)
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show more...
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Zhai, Ranran (author)
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Timmers, Paul R H J (author)
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Li, Ting (author)
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Twait, Emma L (author)
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May-Wilson, Sebastian (author)
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Muckian, Marisa D (author)
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Prins, Bram P (author)
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Png, Grace (author)
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Kooperberg, Charles (author)
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Johansson, Åsa (author)
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Hillary, Robert F (author)
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Wheeler, Eleanor (author)
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- Pan, Lu (author)
- Karolinska Institutet
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He, Yazhou (author)
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- Klasson, Sofia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Ahmad, Shahzad (author)
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Peters, James E (author)
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Gilly, Arthur (author)
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Karaleftheri, Maria (author)
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Tsafantakis, Emmanouil (author)
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Haessler, Jeffrey (author)
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Gyllensten, Ulf (author)
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Harris, Sarah E (author)
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Wareham, Nicholas J (author)
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Göteson, Andreas (author)
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- Lagging, Cecilia (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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Ikram, Mohammad Arfan (author)
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van Duijn, Cornelia M (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Extern,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,External,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Langenberg, Claudia (author)
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Deary, Ian J (author)
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Marioni, Riccardo E (author)
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Enroth, Stefan (author)
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Reiner, Alexander P (author)
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Dedoussis, George (author)
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Zeggini, Eleftheria (author)
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Butterworth, Adam S (author)
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Mälarstig, Anders (author)
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Wilson, James F (author)
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Navarro, Pau (author)
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Shen, Xia (author)
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2023
- 2023
- English.
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Understanding the genetic basis of neuro-related proteins is essential for dissecting the disease etiology of neuropsychiatric disorders and other complex traits and diseases. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein's heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits as well as complex diseases such as hypertension, high cholesterol, immune-related disorders, and psychiatric disorders. Integrating with established drug information, we validated 13 combinations of protein targets and diseases or side effects with available drugs, while suggesting hundreds of re-purposing and new therapeutic targets for diseases and comorbidities. This consortium effort provides a large-scale proteogenomic resource for biomedical research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Repetto, Linda
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Chen, Jiantao
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Yang, Zhijian
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Zhai, Ranran
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Timmers, Paul R ...
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Li, Ting
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show more...
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Twait, Emma L
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May-Wilson, Seba ...
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Muckian, Marisa ...
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Prins, Bram P
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Png, Grace
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Kooperberg, Char ...
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Johansson, Åsa
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Hillary, Robert ...
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Wheeler, Eleanor
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Pan, Lu
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He, Yazhou
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Klasson, Sofia
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Ahmad, Shahzad
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Peters, James E
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Gilly, Arthur
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Karaleftheri, Ma ...
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Tsafantakis, Emm ...
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Haessler, Jeffre ...
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Gyllensten, Ulf
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Harris, Sarah E
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Wareham, Nichola ...
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Göteson, Andreas
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Lagging, Cecilia
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Ikram, Mohammad ...
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van Duijn, Corne ...
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Jern, Christina, ...
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Landén, Mikael, ...
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Langenberg, Clau ...
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Deary, Ian J
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Marioni, Riccard ...
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Enroth, Stefan
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Reiner, Alexande ...
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Dedoussis, Georg ...
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Zeggini, Elefthe ...
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Butterworth, Ada ...
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Mälarstig, Ander ...
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Wilson, James F
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Navarro, Pau
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Shen, Xia
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
- medRxiv : the pr ...
- By the university
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University of Gothenburg
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Karolinska Institutet