Search: onr:"swepub:oai:gup.ub.gu.se/324801" > Radiomics-Derived B...
Fältnamn | Indikatorer | Metadata |
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000 | 07920naa a2201201 4500 | |
001 | oai:gup.ub.gu.se/324801 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:eb6aa270-e523-4ae8-ad6a-57f93dd810c2 | |
024 | 7 | a https://gup.ub.gu.se/publication/3248012 URI |
024 | 7 | a https://doi.org/10.1212/WNL.00000000002015962 DOI |
024 | 7 | a https://lup.lub.lu.se/record/eb6aa270-e523-4ae8-ad6a-57f93dd810c22 URI |
040 | a (SwePub)gud (SwePub)lu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bretzner, Martinu University of Lille,Massachusetts General Hospital,Harvard Medical School4 aut |
245 | 1 0 | a Radiomics-Derived Brain Age Predicts Functional Outcome After Acute Ischemic Stroke. |
264 | 1 | c 2023 |
520 | a While chronological age is one of the most influential determinants of poststroke outcomes, little is known of the impact of neuroimaging-derived biological "brain age." We hypothesized that radiomics analyses of T2-FLAIR images texture would provide brain age estimates and that advanced brain age of patients with stroke will be associated with cardiovascular risk factors and worse functional outcomes.We extracted radiomics from T2-FLAIR images acquired during acute stroke clinical evaluation. Brain age was determined from brain parenchyma radiomics using an ElasticNet linear regression model. Subsequently, relative brain age (RBA), which expresses brain age in comparison with chronological age-matched peers, was estimated. Finally, we built a linear regression model of RBA using clinical cardiovascular characteristics as inputs and a logistic regression model of favorable functional outcomes taking RBA as input.We reviewed 4,163 patients from a large multisite ischemic stroke cohort (mean age = 62.8 years, 42.0% female patients). T2-FLAIR radiomics predicted chronological ages (mean absolute error = 6.9 years, r = 0.81). After adjustment for covariates, RBA was higher and therefore described older-appearing brains in patients with hypertension, diabetes mellitus, a history of smoking, and a history of a prior stroke. In multivariate analyses, age, RBA, NIHSS, and a history of prior stroke were all significantly associated with functional outcome (respective adjusted odds ratios: 0.58, 0.76, 0.48, 0.55; all p-values < 0.001). Moreover, the negative effect of RBA on outcome was especially pronounced in minor strokes.T2-FLAIR radiomics can be used to predict brain age and derive RBA. Older-appearing brains, characterized by a higher RBA, reflect cardiovascular risk factor accumulation and are linked to worse outcomes after stroke. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Child | |
653 | a Female | |
653 | a Humans | |
653 | a Male | |
653 | a Middle Aged | |
653 | a Brain | |
653 | a diagnostic imaging | |
653 | a Brain Ischemia | |
653 | a diagnostic imaging | |
653 | a complications | |
653 | a Ischemic Stroke | |
653 | a complications | |
653 | a Magnetic Resonance Imaging | |
653 | a methods | |
653 | a Stroke | |
653 | a complications | |
700 | 1 | a Bonkhoff, Anna K4 aut |
700 | 1 | a Schirmer, Markus D4 aut |
700 | 1 | a Hong, Sungmin4 aut |
700 | 1 | a Dalca, Adrian4 aut |
700 | 1 | a Donahue, Kathleen4 aut |
700 | 1 | a Giese, Anne-Katrin4 aut |
700 | 1 | a Etherton, Mark R4 aut |
700 | 1 | a Rist, Pamela M4 aut |
700 | 1 | a Nardin, Marco4 aut |
700 | 1 | a Regenhardt, Robert W4 aut |
700 | 1 | a Leclerc, Xavier4 aut |
700 | 1 | a Lopes, Renaud4 aut |
700 | 1 | a Gautherot, Morgan4 aut |
700 | 1 | a Wang, Clinton4 aut |
700 | 1 | a Benavente, Oscar R4 aut |
700 | 1 | a Wasselius, Johanu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups4 aut0 (Swepub:lu)oft-jws |
700 | 1 | a Donatti, Amanda4 aut |
700 | 1 | a Griessenauer, Christoph4 aut |
700 | 1 | a Heitsch, Laura4 aut |
700 | 1 | a Holmegaard, Margareta,d 1942u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xholmm |
700 | 1 | a Jood, Katarina,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjooka |
700 | 1 | a Jimenez-Conde, Jordi4 aut |
700 | 1 | a Kittner, Steven J4 aut |
700 | 1 | a Lemmens, Robin4 aut |
700 | 1 | a Levi, Christopher R4 aut |
700 | 1 | a McArdle, Patrick F4 aut |
700 | 1 | a McDonough, Caitrin W4 aut |
700 | 1 | a Meschia, James F4 aut |
700 | 1 | a Phuah, Chia-Ling4 aut |
700 | 1 | a Rolfs, Arndt4 aut |
700 | 1 | a Ropele, Stefan4 aut |
700 | 1 | a Rosand, Jonathan4 aut |
700 | 1 | a Roquer, Jaume4 aut |
700 | 1 | a Rundek, Tatjana4 aut |
700 | 1 | a Sacco, Ralph L4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Sharma, Pankaj4 aut |
700 | 1 | a Slowik, Agnieszka4 aut |
700 | 1 | a Sousa, Alessandro4 aut |
700 | 1 | a Stanne, Tara M,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xmcdta |
700 | 1 | a Strbian, Daniel4 aut |
700 | 1 | a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt |
700 | 1 | a Thijs, Vincent4 aut |
700 | 1 | a Vagal, Achala4 aut |
700 | 1 | a Wasselius, Johan4 aut |
700 | 1 | a Woo, Daniel4 aut |
700 | 1 | a Wu, Ona4 aut |
700 | 1 | a Zand, Ramin4 aut |
700 | 1 | a Worrall, Bradford B4 aut |
700 | 1 | a Maguire, Jane4 aut |
700 | 1 | a Lindgren, Arneu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)neur-ali |
700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xjerch |
700 | 1 | a Golland, Polina4 aut |
700 | 1 | a Kuchcinski, Grégory4 aut |
700 | 1 | a Rost, Natalia Su Massachusetts General Hospital,Harvard Medical School4 aut |
710 | 2 | a University of Lilleb Massachusetts General Hospital4 org |
710 | 2 | a International Stroke Genetics Consortium |
773 | 0 | t Neurologyg 100:8q 100:8x 1526-632Xx 0028-3878 |
856 | 4 | u http://dx.doi.org/10.1212/WNL.0000000000201596y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/324801 |
856 | 4 8 | u https://doi.org/10.1212/WNL.0000000000201596 |
856 | 4 8 | u https://lup.lub.lu.se/record/eb6aa270-e523-4ae8-ad6a-57f93dd810c2 |
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