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Sex differences in ...
Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium
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Gong, J. (author)
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Harris, K. (author)
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Lipnicki, D. M. (author)
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show more...
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Castro-Costa, E. (author)
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Lima-Costa, M. F. (author)
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Diniz, B. S. (author)
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Xiao, S. F. (author)
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Lipton, R. B. (author)
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Katz, M. J. (author)
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Wang, C. L. (author)
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Preux, P. M. (author)
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Guerchet, M. (author)
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Gbessemehlan, A. (author)
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Ritchie, K. (author)
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Ancelin, M. L. (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Najar, Jenna, 1990 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Rydberg Sterner, Therese (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Scarmeas, N. (author)
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Yannakoulia, M. (author)
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Kosmidis, M. H. (author)
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Guaita, A. (author)
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Rolandi, E. (author)
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Davin, A. (author)
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Gureje, O. (author)
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Trompet, S. (author)
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Gussekloo, J. (author)
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Riedel-Heller, S. (author)
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Pabst, A. (author)
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Rohr, S. (author)
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Shahar, S. (author)
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Singh, D. K. A. (author)
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Rivan, N. F. M. (author)
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van Boxtel, M. (author)
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Kohler, S. (author)
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Ganguli, M. (author)
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Chang, C. C. (author)
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Jacobsen, E. (author)
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Haan, M. (author)
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Ding, D. (author)
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Zhao, Q. H. (author)
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Xiao, Z. X. (author)
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Narazaki, K. (author)
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Chen, T. (author)
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Chen, S. M. (author)
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Ng, T. P. (author)
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Gwee, X. (author)
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Numbers, K. (author)
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Mather, K. A. (author)
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Scazufca, M. (author)
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Lobo, A. (author)
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De-la-Camara, C. (author)
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Lobo, E. (author)
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Sachdev, P. S. (author)
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Brodaty, H. (author)
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Hackett, M. L. (author)
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Peters, S. A. E. (author)
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Woodward, M. (author)
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(creator_code:org_t)
- 2023-02-15
- 2023
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:8, s. 3365-3378
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- data harmonization
- dementia
- diversity
- risk factor
- sex difference
- middle-income countries
- alzheimer-disease incidence
- apolipoprotein-e
- genotype
- incidence rates
- vascular dementia
- population
- gender
- prevention
- women
- time
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gong, J.
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Harris, K.
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Lipnicki, D. M.
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Castro-Costa, E.
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Lima-Costa, M. F ...
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Diniz, B. S.
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show more...
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Xiao, S. F.
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Lipton, R. B.
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Katz, M. J.
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Wang, C. L.
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Preux, P. M.
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Guerchet, M.
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Gbessemehlan, A.
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Ritchie, K.
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Ancelin, M. L.
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Skoog, Ingmar, 1 ...
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Najar, Jenna, 19 ...
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Rydberg Sterner, ...
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Scarmeas, N.
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Yannakoulia, M.
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Kosmidis, M. H.
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Guaita, A.
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Rolandi, E.
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Davin, A.
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Gureje, O.
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Trompet, S.
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Gussekloo, J.
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Riedel-Heller, S ...
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Pabst, A.
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Rohr, S.
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Shahar, S.
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Singh, D. K. A.
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Rivan, N. F. M.
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van Boxtel, M.
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Kohler, S.
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Ganguli, M.
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Chang, C. C.
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Jacobsen, E.
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Haan, M.
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Ding, D.
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Zhao, Q. H.
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Xiao, Z. X.
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Narazaki, K.
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Chen, T.
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Chen, S. M.
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Ng, T. P.
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Gwee, X.
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Numbers, K.
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Mather, K. A.
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Scazufca, M.
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Lobo, A.
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De-la-Camara, C.
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Lobo, E.
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Sachdev, P. S.
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Brodaty, H.
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Hackett, M. L.
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Peters, S. A. E.
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Woodward, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg
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Karolinska Institutet