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- Gong, J. (author)
Sex differences in dementia risk and risk factors: Individual-participant data analysis using 21 cohorts across six continents from the COSMIC consortium
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023-02-15
- Wiley,2023
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- LIBRIS-ID:oai:gup.ub.gu.se/325020
- https://gup.ub.gu.se/publication/325020URI
- https://doi.org/10.1002/alz.12962DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152095773URI
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- Language:English
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- IntroductionSex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. MethodsA total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. ResultsIncident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DiscussionDementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- data harmonization
- dementia
- diversity
- risk factor
- sex difference
- middle-income countries
- alzheimer-disease incidence
- apolipoprotein-e
- genotype
- incidence rates
- vascular dementia
- population
- gender
- prevention
- women
- time
- Neurosciences & Neurology
Added entries (persons, corporate bodies, meetings, titles ...)
- Harris, K. (author)
- Lipnicki, D. M. (author)
- Castro-Costa, E. (author)
- Lima-Costa, M. F. (author)
- Diniz, B. S. (author)
- Xiao, S. F. (author)
- Lipton, R. B. (author)
- Katz, M. J. (author)
- Wang, C. L. (author)
- Preux, P. M. (author)
- Guerchet, M. (author)
- Gbessemehlan, A. (author)
- Ritchie, K. (author)
- Ancelin, M. L. (author)
- Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xskooi (author)
- Najar, Jenna,1990Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xalnje (author)
- Rydberg Sterner, ThereseKarolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)(Swepub:gu)xrydbt (author)
- Scarmeas, N. (author)
- Yannakoulia, M. (author)
- Kosmidis, M. H. (author)
- Guaita, A. (author)
- Rolandi, E. (author)
- Davin, A. (author)
- Gureje, O. (author)
- Trompet, S. (author)
- Gussekloo, J. (author)
- Riedel-Heller, S. (author)
- Pabst, A. (author)
- Rohr, S. (author)
- Shahar, S. (author)
- Singh, D. K. A. (author)
- Rivan, N. F. M. (author)
- van Boxtel, M. (author)
- Kohler, S. (author)
- Ganguli, M. (author)
- Chang, C. C. (author)
- Jacobsen, E. (author)
- Haan, M. (author)
- Ding, D. (author)
- Zhao, Q. H. (author)
- Xiao, Z. X. (author)
- Narazaki, K. (author)
- Chen, T. (author)
- Chen, S. M. (author)
- Ng, T. P. (author)
- Gwee, X. (author)
- Numbers, K. (author)
- Mather, K. A. (author)
- Scazufca, M. (author)
- Lobo, A. (author)
- De-la-Camara, C. (author)
- Lobo, E. (author)
- Sachdev, P. S. (author)
- Brodaty, H. (author)
- Hackett, M. L. (author)
- Peters, S. A. E. (author)
- Woodward, M. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
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- In:Alzheimers & Dementia: Wiley19:8, s. 3365-33781552-52601552-5279
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