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International Conse...
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
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- Hokken-Koelega, A. C. S. (author)
- Karolinska Institutet
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van der Steen, M. (author)
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Boguszewski, M. C. S. (author)
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Cianfarani, S. (author)
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- Dahlgren, Jovanna, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Horikawa, R. (author)
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Mericq, V. (author)
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Rapaport, R. (author)
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Alherbish, A. (author)
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Braslavsky, D. (author)
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Charmandari, E. (author)
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Chernausek, S. D. (author)
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Cutfield, W. S. (author)
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Dauber, A. (author)
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Deeb, A. (author)
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Goedegebuure, W. J. (author)
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Hofman, P. L. (author)
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Isganatis, E. (author)
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Jorge, A. A. (author)
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Kanaka-Gantenbein, C. (author)
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Kashimada, K. (author)
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Khadilkar, V. (author)
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Luo, X. P. (author)
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Mathai, S. (author)
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Nakano, Y. (author)
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Yau, M. (author)
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(creator_code:org_t)
- 2023-01-13
- 2023
- English.
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In: Endocrine Reviews. - : The Endocrine Society. - 0163-769X .- 1945-7189. ; 44:3, s. 539-565
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Abstract
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- This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups. To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < -2.5 SDS at age 2 years or < -2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- SGA
- etiology
- consequences
- management
- genetics
- GH
- growth-hormone treatment
- bone-mineral density
- catch-up growth
- cardiovascular risk-factors
- copy number variants
- long-term mortality
- children born sga
- quality-of-life
- reduced insulin sensitivity
- central
- precocious puberty
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hokken-Koelega, ...
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van der Steen, M ...
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Boguszewski, M. ...
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Cianfarani, S.
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Dahlgren, Jovann ...
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Horikawa, R.
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show more...
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Mericq, V.
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Rapaport, R.
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Alherbish, A.
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Braslavsky, D.
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Charmandari, E.
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Chernausek, S. D ...
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Cutfield, W. S.
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Dauber, A.
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Deeb, A.
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Goedegebuure, W. ...
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Hofman, P. L.
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Isganatis, E.
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Jorge, A. A.
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Kanaka-Gantenbei ...
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Kashimada, K.
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Khadilkar, V.
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Luo, X. P.
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Mathai, S.
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Nakano, Y.
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Yau, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Endocrine Review ...
- By the university
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University of Gothenburg
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Karolinska Institutet