Search: onr:"swepub:oai:gup.ub.gu.se/325061" >
Plasma proteomic ch...
Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations.
-
- Robbins, Jeremy M (author)
- Beth Israel Deaconess Medical Center
-
- Rao, Prashant (author)
- Beth Israel Deaconess Medical Center
-
- Deng, Shuliang (author)
- Beth Israel Deaconess Medical Center
-
show more...
-
- Keyes, Michelle J (author)
- Beth Israel Deaconess Medical Center,Framingham Heart Study
-
- Tahir, Usman A (author)
- Beth Israel Deaconess Medical Center
-
- Katz, Daniel H (author)
- Beth Israel Deaconess Medical Center
-
- Beltran, Pierre M Jean (author)
- Broad Institute
-
- Marchildon, François (author)
- Rockefeller University
-
- Barber, Jacob L (author)
- University of South Carolina
-
- Peterson, Bennet (author)
- Beth Israel Deaconess Medical Center
-
- Gao, Yan (author)
- University of Mississippi Medical Center
-
- Correa, Adolfo (author)
- University of Mississippi Medical Center
-
- Wilson, James G (author)
- Beth Israel Deaconess Medical Center,University of Mississippi Medical Center
-
- Smith, J. Gustav, 1982 (author)
- University of Gothenburg,Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital,Sahlgrenska University Hospital,Broad Institute
-
- Cohen, Paul (author)
- Rockefeller University
-
- Ross, Robert (author)
- Queen's University at Kingston
-
- Bouchard, Claude (author)
- Pennington Biomedical Research Center
-
- Sarzynski, Mark A (author)
- University of South Carolina
-
- Gerszten, Robert E (author)
- Broad Institute,Beth Israel Deaconess Medical Center
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: JCI insight. - 2379-3708. ; 8:7
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supervised, 20-week endurance exercise training intervention. We identify hundreds of circulating proteins that are modulated, many of which are known to be secreted. We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protein relevant in body-composition homeostasis. We relate protein changes to training-induced maximal oxygen uptake adaptations and validate our top findings in an external exercise cohort. Furthermore, we show that FAP is positively associated with survival in 3 separate, population-based cohorts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Keyword
- Humans
- Cardiorespiratory Fitness
- Proteomics
- Muscle
- Skeletal
- metabolism
- Exercise
- physiology
- Adaptation
- Physiological
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Robbins, Jeremy ...
-
Rao, Prashant
-
Deng, Shuliang
-
Keyes, Michelle ...
-
Tahir, Usman A
-
Katz, Daniel H
-
show more...
-
Beltran, Pierre ...
-
Marchildon, Fran ...
-
Barber, Jacob L
-
Peterson, Bennet
-
Gao, Yan
-
Correa, Adolfo
-
Wilson, James G
-
Smith, J. Gustav ...
-
Cohen, Paul
-
Ross, Robert
-
Bouchard, Claude
-
Sarzynski, Mark ...
-
Gerszten, Robert ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Physiology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Sport and Fitnes ...
- Articles in the publication
-
JCI insight
- By the university
-
University of Gothenburg
-
Lund University