Genetic effects on the timing of parturition and links to fetal birth weight.

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Fältnamn	Indikatorer	Metadata
000		06646naa a2201273 4500
001		oai:gup.ub.gu.se/325091
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3250912 URI
024	7	a https://doi.org/10.1038/s41588-023-01343-92 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Solé Navais, Polu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsolpo
245	1 0	a Genetic effects on the timing of parturition and links to fetal birth weight.
264	1	c 2023
520		a The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n=195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration. Analysis of the parental transmitted and nontransmitted alleles (n=136,833) shows that 15 of the gestational duration genetic variants act through the maternal genome, whereas 7 act both through the maternal and fetal genomes and 2 act only via the fetal genome. Finally, the maternal effects on gestational duration show signs of antagonistic pleiotropy with the fetal effects on birth weight: maternal alleles that increase gestational duration have negative fetal effects on birth weight. The present study provides insights into the genetic effects on the timing of parturition and the complex maternal-fetal relationship between gestational duration and birth weight.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
700	1	a Flatley, Christopheru Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xflchr
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Vaudel, Marc4 aut
700	1	a Juodakis, Juliusu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjouju
700	1	a Chen, Jing4 aut
700	1	a Laisk, Triin4 aut
700	1	a LaBella, Abigail L4 aut
700	1	a Westergaard, David4 aut
700	1	a Bacelis, Jonas,d 1984u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xbacjo
700	1	a Brumpton, Ben4 aut
700	1	a Skotte, Line4 aut
700	1	a Borges, Maria C4 aut
700	1	a Helgeland, Øyvind4 aut
700	1	a Mahajan, Anubha4 aut
700	1	a Wielscher, Matthias4 aut
700	1	a Lin, Frederick4 aut
700	1	a Briggs, Catherine4 aut
700	1	a Wang, Carol A4 aut
700	1	a Moen, Gunn-Helen4 aut
700	1	a Beaumont, Robin N4 aut
700	1	a Bradfield, Jonathan P4 aut
700	1	a Abraham, Abin4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Gabrielsen, Maiken E4 aut
700	1	a Ostrowski, Sisse R4 aut
700	1	a Modzelewska, Dominika4 aut
700	1	a Nohr, Ellen A4 aut
700	1	a Hypponen, Elina4 aut
700	1	a Srivastava, Amit4 aut
700	1	a Talbot, Octavious4 aut
700	1	a Allard, Catherine4 aut
700	1	a Williams, Scott M4 aut
700	1	a Menon, Ramkumar4 aut
700	1	a Shields, Beverley M4 aut
700	1	a Sveinbjornsson, Gardar4 aut
700	1	a Xu, Huan4 aut
700	1	a Melbye, Mads4 aut
700	1	a Lowe, William4 aut
700	1	a Bouchard, Luigi4 aut
700	1	a Oken, Emily4 aut
700	1	a Pedersen, Ole B4 aut
700	1	a Gudbjartsson, Daniel F4 aut
700	1	a Erikstrup, Christian4 aut
700	1	a Sørensen, Erik4 aut
700	1	a Lie, Rolv T4 aut
700	1	a Teramo, Kari4 aut
700	1	a Hallman, Mikko4 aut
700	1	a Juliusdottir, Thorhildur4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Ullum, Henrik4 aut
700	1	a Hattersley, Andrew T4 aut
700	1	a Sletner, Line4 aut
700	1	a Merialdi, Mario4 aut
700	1	a Rifas-Shiman, Sheryl L4 aut
700	1	a Steingrimsdottir, Thora4 aut
700	1	a Scholtens, Denise4 aut
700	1	a Power, Christine4 aut
700	1	a West, Jane4 aut
700	1	a Nyegaard, Mette4 aut
700	1	a Capra, John A4 aut
700	1	a Skogholt, Anne H4 aut
700	1	a Magnus, Per4 aut
700	1	a Andreassen, Ole A4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Qvigstad, Elisabeth4 aut
700	1	a Pennell, Craig E4 aut
700	1	a Hivert, Marie-France4 aut
700	1	a Hayes, Geoffrey M4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a Lawlor, Deborah A4 aut
700	1	a Nielsen, Henriette S4 aut
700	1	a Mägi, Reedik4 aut
700	1	a Rokas, Antonis4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Njolstad, Pål4 aut
700	1	a Muglia, Louis J4 aut
700	1	a Freathy, Rachel M4 aut
700	1	a Johanson, Stefan4 aut
700	1	a Zhang, Ge4 aut
700	1	a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t Nature geneticsg 55:4, s. 559-567q 55:4<559-567x 1546-1718
856	4 8	u https://gup.ub.gu.se/publication/325091
856	4 8	u https://doi.org/10.1038/s41588-023-01343-9

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By the author/editor: Solé Navais, Pol; Flatley, Christo ...; Steinthorsdottir ...; Vaudel, Marc; Juodakis, Julius; Chen, Jing; show more...; Laisk, Triin; LaBella, Abigail ...; Westergaard, Dav ...; Bacelis, Jonas, ...; Brumpton, Ben; Skotte, Line; Borges, Maria C; Helgeland, Øyvin ...; Mahajan, Anubha; Wielscher, Matth ...; Lin, Frederick; Briggs, Catherin ...; Wang, Carol A; Moen, Gunn-Helen; Beaumont, Robin ...; Bradfield, Jonat ...; Abraham, Abin; Thorleifsson, Gu ...; Gabrielsen, Maik ...; Ostrowski, Sisse ...; Modzelewska, Dom ...; Nohr, Ellen A; Hypponen, Elina; Srivastava, Amit; Talbot, Octaviou ...; Allard, Catherin ...; Williams, Scott ...; Menon, Ramkumar; Shields, Beverle ...; Sveinbjornsson, ...; Xu, Huan; Melbye, Mads; Lowe, William; Bouchard, Luigi; Oken, Emily; Pedersen, Ole B; Gudbjartsson, Da ...; Erikstrup, Chris ...; Sørensen, Erik; Lie, Rolv T; Teramo, Kari; Hallman, Mikko; Juliusdottir, Th ...; Hakonarson, Hako ...; Ullum, Henrik; Hattersley, Andr ...; Sletner, Line; Merialdi, Mario; Rifas-Shiman, Sh ...; Steingrimsdottir ...; Scholtens, Denis ...; Power, Christine; West, Jane; Nyegaard, Mette; Capra, John A; Skogholt, Anne H; Magnus, Per; Andreassen, Ole ...; Thorsteinsdottir ...; Grant, Struan F ...; Qvigstad, Elisab ...; Pennell, Craig E; Hivert, Marie-Fr ...; Hayes, Geoffrey ...; Jarvelin, Marjo- ...; McCarthy, Mark I; Lawlor, Deborah ...; Nielsen, Henriet ...; Mägi, Reedik; Rokas, Antonis; Hveem, Kristian; Stefansson, Kari; Feenstra, Bjarke; Njolstad, Pål; Muglia, Louis J; Freathy, Rachel ...; Johanson, Stefan; Zhang, Ge; Jacobsson, Bo, 1 ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: Nature genetics

By the university: University of Gothenburg

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