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Decreased Cerebrosp...
Decreased Cerebrospinal Fluid Amyloid beta 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid Angiopathy
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De Kort, A. M. (author)
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Kuiperij, H. B. (author)
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Marques, T. M. (author)
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Jakel, L. (author)
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van den Berg, E. (author)
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Kersten, I. (author)
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van Berckel-Smit, H. E. P. (author)
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Duering, M. (author)
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Stoops, E. (author)
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Abdo, W. F. (author)
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Rasing, I. (author)
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Voigt, S. (author)
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Koemans, E. A. (author)
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Kaushik, K. (author)
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Warren, A. D. (author)
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Greenberg, S. M. (author)
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- Brinkmalm, Gunnar (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Terwindt, G. M. (author)
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Wermer, M. J. H. (author)
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Schreuder, Fhbm (author)
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Klijn, C. J. M. (author)
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Verbeek, M. M. (author)
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(creator_code:org_t)
- 2023-02-20
- 2023
- English.
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In: Annals of neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 93:6, s. 1173-86
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https://doi.org/10.1...
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Abstract
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- Objective: Vascular amyloid beta (A beta) accumulation is the hallmark of cerebral amyloid angiopathy (CAA). The composition of cerebrospinal fluid (CSF) of CAA patients may serve as a diagnostic biomarker of CAA. We studied the diagnostic potential of the peptides A beta 38, A beta 40, A beta 42, and A beta 43 in patients with sporadic CAA (sCAA), hereditary Dutch-type CAA (D-CAA), and Alzheimer disease (AD).Methods: A beta peptides were quantified by immunoassays in a discovery group (26 patients with sCAA and 40 controls), a validation group (40 patients with sCAA, 40 patients with AD, and 37 controls), and a group of 22 patients with D-CAA and 54 controls. To determine the diagnostic accuracy, the area under the curve (AUC) was calculated using a receiver operating characteristic curve with 95% confidence interval (CI).Results: We found decreased levels of all A beta peptides in sCAA patients and D-CAA patients compared to controls. The difference was most prominent for A beta 42 (AUC of sCAA vs controls for discovery: 0.90, 95% CI = 0.82-0.99; for validation: 0.94, 95% CI = 0.89-0.99) and A beta 43 (AUC of sCAA vs controls for discovery: 0.95, 95% CI = 0.88-1.00; for validation: 0.91, 95% CI = 0.83-1.0). All A beta peptides except A beta 43 were also decreased in sCAA compared to AD (CSF A beta 38: AUC = 0.82, 95% CI = 0.71-0.93; CSF A beta 40: AUC = 0.88, 95% CI = 0.80-0.96; CSF A beta 42: AUC = 0.79, 95% CI = 0.66-0.92).Interpretation: A combined biomarker panel of CSF A beta 38, A beta 40, A beta 42, and A beta 43 has potential to differentiate sCAA from AD and controls, and D-CAA from controls. ANN NEUROL 2023
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- small-vessel disease
- alzheimers-disease
- superficial siderosis
- hemorrhage
- biomarker
- dutch
- a-beta-42
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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De Kort, A. M.
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Kuiperij, H. B.
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Marques, T. M.
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Jakel, L.
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van den Berg, E.
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Kersten, I.
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show more...
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van Berckel-Smit ...
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Duering, M.
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Stoops, E.
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Abdo, W. F.
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Rasing, I.
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Voigt, S.
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Koemans, E. A.
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Kaushik, K.
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Warren, A. D.
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Greenberg, S. M.
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Brinkmalm, Gunna ...
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Terwindt, G. M.
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Wermer, M. J. H.
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Schreuder, Fhbm
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Klijn, C. J. M.
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Verbeek, M. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Annals of neurol ...
- By the university
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University of Gothenburg