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Proteolytic process...
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
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Bülck, Cynthia (author)
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Nyström, Elisabeth E.L. (author)
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Koudelka, Tomas (author)
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Mannbar-Frahm, Michael (author)
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Andresen, Gerrit (author)
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Radhouani, Mariem (author)
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Tran, Florian (author)
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Scharfenberg, Franka (author)
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Schrell, Friederike (author)
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Armbrust, Fred (author)
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Dahlke, Eileen (author)
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Zhao, Bei (author)
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Vervaeke, Alex (author)
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Theilig, Franziska (author)
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Rosenstiel, Philip (author)
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Starkl, Philipp (author)
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Rosshart, Stephan P. (author)
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Fickenscher, Helmut (author)
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Tholey, Andreas (author)
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- Hansson, Gunnar C., 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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Becker-Pauly, Christoph (author)
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(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2023
- 2023
- English.
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In: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 9:13
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a protective role in mucosal homeostasis. In the colon, meprin α and meprin β form covalently linked heterodimers tethering meprin α to the plasma membrane, therefore presenting dual proteolytic activity in a unique enzyme complex. To unravel its function, we applied N-terminomics and identified galectin-3 as the major intestinal substrate for meprin α/β heterodimers. Galectin-3-deficient and meprin α/β double knockout mice show similar alterations in their microbiome in comparison to wild-type mice. We further demonstrate that meprin α/β heterodimers differentially process galectin-3 upon bacterial infection, in germ-free, conventionally housed (specific pathogen-free), or wildling mice, which in turn regulates the bacterial agglutination properties of galectin-3. Thus, the constitutive cleavage of galectin-3 by meprin α/β heterodimers may play a key role in colon host-microbiome homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bülck, Cynthia
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Nyström, Elisabe ...
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Koudelka, Tomas
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Mannbar-Frahm, M ...
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Andresen, Gerrit
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Radhouani, Marie ...
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show more...
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Tran, Florian
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Scharfenberg, Fr ...
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Schrell, Frieder ...
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Armbrust, Fred
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Dahlke, Eileen
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Zhao, Bei
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Vervaeke, Alex
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Theilig, Franzis ...
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Rosenstiel, Phil ...
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Starkl, Philipp
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Rosshart, Stepha ...
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Fickenscher, Hel ...
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Tholey, Andreas
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Hansson, Gunnar ...
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Becker-Pauly, Ch ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Science advances
- By the university
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University of Gothenburg