Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.

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Fältnamn	Indikatorer	Metadata
000		10140naa a2202245 4500
001		oai:gup.ub.gu.se/325710
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:236824922
024	7	a https://gup.ub.gu.se/publication/3257102 URI
024	7	a https://doi.org/10.21203/rs.3.rs-2580252/v12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2368249222 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Amare, Azmeraw4 aut
245	1 0	a Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder.
264	1	b Research Square Platform LLC,c 2023
520		a Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li+PGS) in patients with BD. To gain further insights into lithium's possible molecular mechanism of action, we performed a genome-wide gene-based analysis. Using polygenic score modeling, via methods incorporating Bayesian regression and continuous shrinkage priors, Li+PGS was developed in the International Consortium of Lithium Genetics cohort (ConLi+Gen: N=2,367) and replicated in the combined PsyCourse (N=89) and BipoLife (N=102) studies. The associations of Li+PGS and lithium treatment response - defined in a continuous ALDA scale and a categorical outcome (good response vs. poor response) were tested using regression models, each adjusted for the covariates: age, sex, and the first four genetic principal components. Statistical significance was determined at P<��.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Thalamuthu, Anbupalam4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Fullerton, Janice4 aut
700	1	a Ahmed, Muktar4 aut
700	1	a Hartmann, Simon4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Tekola-Ayele, Fasil4 aut
700	1	a Hou, Liping4 aut
700	1	a Hsu, Yi-Hsiang4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antoni4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Biernacka, Joanna4 aut
700	1	a Birner, Armin4 aut
700	1	a Marie-Claire, Cynthia4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Zompo, Maria Del4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Etain, Bruno4 aut
700	1	a Jamain, Stéphane4 aut
700	1	a Falkai, Peter4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisén, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie4 aut
700	1	a Goes, Fernando4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Fallgatter, Andreas4 aut
700	1	a Stegmaier, Sophia4 aut
700	1	a Ethofer, Thomas4 aut
700	1	a Biere, Silvia4 aut
700	1	a Petrova, Kristiyana4 aut
700	1	a Schuster, Ceylan4 aut
700	1	a Adorjan, Kristina4 aut
700	1	a Budde, Monika4 aut
700	1	a Heilbronner, Maria4 aut
700	1	a Kalman, Janos4 aut
700	1	a Kohshour, Mojtaba Oraki4 aut
700	1	a Reich-Erkelenz, Daniela4 aut
700	1	a Schaupp, Sabrina4 aut
700	1	a Schulte, Eva4 aut
700	1	a Senner, Fanny4 aut
700	1	a Vogl, Thomas4 aut
700	1	a Anghelescu, Ion-George4 aut
700	1	a Arolt, Volker4 aut
700	1	a Dannlowski, Udo4 aut
700	1	a Dietrich, Detlef E4 aut
700	1	a Figge, Christian4 aut
700	1	a Jäger, Markus4 aut
700	1	a Lang, Fabian4 aut
700	1	a Juckel, Georg4 aut
700	1	a Spitzer, Carsten4 aut
700	1	a Reimer, Jens4 aut
700	1	a Schmauß, Max4 aut
700	1	a Schmitt, Andrea4 aut
700	1	a Konrad, Carsten4 aut
700	1	a von Hagen, Martin4 aut
700	1	a Wiltfang, Jens4 aut
700	1	a Zimmermann, Jörg4 aut
700	1	a Andlauer, Till4 aut
700	1	a Fischer, Andre4 aut
700	1	a Bermpohl, Felix4 aut
700	1	a Kraft, Vivien4 aut
700	1	a Matura, Silke4 aut
700	1	a Gryaznova, Anna4 aut
700	1	a Falkenberg, Irina4 aut
700	1	a Yildiz, Cüneyt4 aut
700	1	a Kircher, Tilo4 aut
700	1	a Schmidt, Julia4 aut
700	1	a Koch, Marius4 aut
700	1	a Gade, Katrin4 aut
700	1	a Trost, Sarah4 aut
700	1	a Haußleiter, Ida4 aut
700	1	a Lambert, Martin4 aut
700	1	a Rohenkohl, Anja C4 aut
700	1	a Kraft, Vivien4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a König, Barbara4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Manchia, Mirkou Karolinska Institutet4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael4 aut
700	1	a McElroy, Susan L4 aut
700	1	a Colom, Francesc4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline4 aut
700	1	a Nöthen, Markus4 aut
700	1	a Novak, Tomas4 aut
700	1	a O'Donovan, Claire4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Pisanu, Claudia4 aut
700	1	a Potash, James4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rouleau, Guy4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Shimoda, Kazutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Maj, Mario4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Veeh, Julia4 aut
700	1	a Witt, Stephanie4 aut
700	1	a Wright, Adam4 aut
700	1	a Zandi, Peter4 aut
700	1	a Mitchell, Philip4 aut
700	1	a Bauer, Michael4 aut
700	1	a Alda, Martin4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a McMahon, Francis4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a Millischer, Vincentu Karolinska Institutet4 aut
700	1	a Clark, Scott4 aut
700	1	a Baune, Bernhard4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Research squared : Research Square Platform LLC
856	4 8	u https://gup.ub.gu.se/publication/325710
856	4 8	u https://doi.org/10.21203/rs.3.rs-2580252/v1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:236824922

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By the author/editor: Amare, Azmeraw; Thalamuthu, Anbu ...; Schubert, Klaus ...; Fullerton, Janic ...; Ahmed, Muktar; Hartmann, Simon; show more...; Papiol, Sergi; Heilbronner, Urs; Degenhardt, Fran ...; Tekola-Ayele, Fa ...; Hou, Liping; Hsu, Yi-Hsiang; Shekhtman, Tatya ...; Adli, Mazda; Akula, Nirmala; Akiyama, Kazufum ...; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Bhattacharjee, A ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Biernacka, Joann ...; Birner, Armin; Marie-Claire, Cy ...; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Cruceanu, Cristi ...; Czerski, Piotr; Dalkner, Nina; Zompo, Maria Del; DePaulo, J Raymo ...; Etain, Bruno; Jamain, Stéphane; Falkai, Peter; Forstner, Andrea ...; Frisén, Louise; Frye, Mark; Gard, Sébastien; Garnham, Julie; Goes, Fernando; Grigoroiu-Serban ...; Fallgatter, Andr ...; Stegmaier, Sophi ...; Ethofer, Thomas; Biere, Silvia; Petrova, Kristiy ...; Schuster, Ceylan; Adorjan, Kristin ...; Budde, Monika; Heilbronner, Mar ...; Kalman, Janos; Kohshour, Mojtab ...; Reich-Erkelenz, ...; Schaupp, Sabrina; Schulte, Eva; Senner, Fanny; Vogl, Thomas; Anghelescu, Ion- ...; Arolt, Volker; Dannlowski, Udo; Dietrich, Detlef ...; Figge, Christian; Jäger, Markus; Lang, Fabian; Juckel, Georg; Spitzer, Carsten; Reimer, Jens; Schmauß, Max; Schmitt, Andrea; Konrad, Carsten; von Hagen, Marti ...; Wiltfang, Jens; Zimmermann, Jörg; Andlauer, Till; Fischer, Andre; Bermpohl, Felix; Kraft, Vivien; Matura, Silke; Gryaznova, Anna; Falkenberg, Irin ...; Yildiz, Cüneyt; Kircher, Tilo; Schmidt, Julia; Koch, Marius; Gade, Katrin; Trost, Sarah; Haußleiter, Ida; Lambert, Martin; Rohenkohl, Anja ...; Grof, Paul; Hashimoto, Ryota; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kuo, Po-Hsiu; Kato, Tadafumi; Kelsoe, John; Kittel-Schneider ...; Ferensztajn-Roch ...; König, Barbara; Kusumi, Ichiro; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Tortorella, Alfo ...; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; Colom, Francesc; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus; Novak, Tomas; O'Donovan, Clair ...; Ozaki, Norio; Pfennig, Andrea; Pisanu, Claudia; Potash, James; Reif, Andreas; Reininghaus, Eva; Rouleau, Guy; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter; Schweizer, Barba ...; Severino, Giovan ...; Shilling, Paul D; Shimoda, Kazutak ...; Simhandl, Christ ...; Slaney, Claire; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Maj, Mario; Turecki, Gustavo; Vieta, Eduard; Veeh, Julia; Witt, Stephanie; Wright, Adam; Zandi, Peter; Mitchell, Philip; Bauer, Michael; Alda, Martin; Rietschel, Marce ...; McMahon, Francis; Schulze, Thomas ...; Millischer, Vinc ...; Clark, Scott; Baune, Bernhard; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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