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Tau pathology as de...
Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study
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- Visser, D. (author)
- Vrije Universiteit Amsterdam
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- Verfaillie, S. C. J. (author)
- Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam
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- Bosch, Iris, 1997 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,Vrije Universiteit Amsterdam
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- Brouwer, I. (author)
- Vrije Universiteit Amsterdam
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- Tuncel, H. (author)
- Vrije Universiteit Amsterdam
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- Coomans, Emma M. (author)
- Vrije Universiteit Amsterdam
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- Rikken, R. M. (author)
- Vrije Universiteit Amsterdam
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- Mastenbroek, Sophie E. (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Vrije Universiteit Amsterdam
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- Golla, S. S. V. (author)
- Vrije Universiteit Amsterdam
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- Barkhof, F. (author)
- University College London,Vrije Universiteit Amsterdam
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- van de Giessen, E. (author)
- Vrije Universiteit Amsterdam
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- van Berckel, B. N. M. (author)
- Vrije Universiteit Amsterdam
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- van der Flier, W. M. (author)
- Vrije Universiteit Amsterdam
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2023-03-28
- 2023
- English.
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In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 50:8, s. 2409-19
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Abstract
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- PurposeTau pathology is associated with concurrent atrophy and decreased cerebral blood flow (CBF) in Alzheimer's disease (AD), but less is known about their temporal relationships. Our aim was therefore to investigate the association of concurrent and longitudinal tau PET with longitudinal changes in atrophy and relative CBF.MethodsWe included 61 individuals from the Amsterdam Dementia Cohort (mean age 65.1 +/- 7.5 years, 44% female, 57% amyloid-beta positive [A beta +], 26 cognitively impaired [CI]) who underwent dynamic [F-18]flortaucipir PET and structural MRI at baseline and 25 +/- 5 months follow-up. In addition, we included 86 individuals (68 CI) who only underwent baseline dynamic [F-18]flortaucipir PET and MRI scans to increase power in our statistical models. We obtained [F-18]flortaucipir PET binding potential (BPND) and R-1 values reflecting tau load and relative CBF, respectively, and computed cortical thickness from the structural MRI scans using FreeSurfer. We assessed the regional associations between i) baseline and ii) annual change in tau PET BPND in Braak I, III/IV, and V/VI regions and cortical thickness or R-1 in cortical gray matter regions (spanning the whole brain) over time using linear mixed models with random intercepts adjusted for age, sex, time between baseline and follow-up assessments, and baseline BPND in case of analyses with annual change as determinant. All analyses were performed in A beta- cognitively normal (CN) individuals and A beta+ (CN and CI) individuals separately.ResultsIn A beta+ individuals, greater baseline Braak III/IV and V/VI tau PET binding was associated with faster cortical thinning in primarily frontotemporal regions. Annual changes in tau PET were not associated with cortical thinning over time in either A beta+ or A beta- individuals. Baseline tau PET was not associated with longitudinal changes in relative CBF, but increases in Braak III/IV tau PET over time were associated with increases in parietal relative CBF over time in A beta + individuals.ConclusionWe showed that higher tau load was related to accelerated cortical thinning, but not to decreases in relative CBF. Moreover, tau PET load at baseline was a stronger predictor of cortical thinning than change of tau PET signal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Tau PET
- Cerebral blood flow
- Atrophy
- Alzheimer's disease
- Longitudinal
- alzheimers-disease
- human brain
- pet
- deposition
- framework
- dementia
- Radiology
- Nuclear Medicine & Medical Imaging
- Alzheimer’s disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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Visser, D.
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Verfaillie, S. C ...
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Bosch, Iris, 199 ...
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Brouwer, I.
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Tuncel, H.
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Coomans, Emma M.
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Rikken, R. M.
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Mastenbroek, Sop ...
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Golla, S. S. V.
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Barkhof, F.
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van de Giessen, ...
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van Berckel, B. ...
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van der Flier, W ...
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Ossenkoppele, Ri ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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European Journal ...
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University of Gothenburg
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Lund University