Search: onr:"swepub:oai:gup.ub.gu.se/326261" >
Design of non-cytot...
Design of non-cytotoxic 6,7-dihydroxycoumarin-5-carboxylates with antibiofilm activity against Staphylococcus aureus and Candida albicans
-
Zscherp, R. (author)
-
- Chakrabarti, Aishi (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
-
Lehmann, A. P. (author)
-
show more...
-
Schrey, H. (author)
-
Zeng, H. X. (author)
-
Collisi, W. (author)
-
- Klahn, Philipp (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,CARe - Centrum för antibiotikaresistensforskning,Department of Chemistry and Molecular Biology,Centre for antibiotic resistance research, CARe
-
show less...
-
(creator_code:org_t)
- 2023
- 2023
- English.
-
In: Organic & Biomolecular Chemistry. - 1477-0520. ; 21:23, s. 4744-9
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The 6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou have been synthesized via five-step route including a propargyl-Claisen rearrangement as key step. The compounds show antibiofilm activity against Stapylococcus aureus and Candida albicans but lack the cytotoxic activity of parent 6,7-dihydroxycoumarines such as esculetin and 4-methylesculetin.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- pseudomonas-aeruginosa biofilm
- antimicrobial agents
- in-vitro
- coumarin
- apoptosis
- resistance
- inhibitors
- induction
- esculetin
- Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database