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An explorative stud...
An explorative study on respiratory health among operators working in polymer additive manufacturing
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- Almstrand, Ann-Charlotte (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Bredberg, A. (author)
- RISE,Metodik för produktframtagning,Res Inst Sweden, Sweden
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- Runström Eden, Gunilla (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Karlsson, Helen (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin
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- Assenhöj, Maria (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Arbets- och miljömedicin
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- Koca Akdeva, Hatice (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Olin, Anna-Carin, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Tinnerberg, Håkan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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(creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- English.
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In: Frontiers in Public Health. - : Frontiers Media S.A.. - 2296-2565. ; 11
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Abstract
Subject headings
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- Additive manufacturing (AM), or 3D printing, is a growing industry involving a wide range of different techniques and materials. The potential toxicological effects of emissions produced in the process, involving both ultrafine particles and volatile organic compounds (VOCs), are unclear, and there are concerns regarding possible health implications among AM operators.The objective of this study was to screen the presence of respiratory health effects among people working with liquid, powdered, or filament plastic materials in AM. MethodsIn total, 18 subjects working with different additive manufacturing techniques and production of filament with polymer feedstock and 20 controls participated in the study. Study subjects filled out a questionnaire and underwent blood and urine sampling, spirometry, impulse oscillometry (IOS), exhaled NO test (FeNO), and collection of particles in exhaled air (PEx), and the exposure was assessed. Analysis of exhaled particles included lung surfactant components such as surfactant protein A (SP-A) and phosphatidylcholines. SP-A and albumin were determined using ELISA. Using reversed-phase liquid chromatography and targeted mass spectrometry, the relative abundance of 15 species of phosphatidylcholine (PC) was determined in exhaled particles. The results were evaluated by univariate and multivariate statistical analyses (principal component analysis). ResultsExposure and emission measurements in AM settings revealed a large variation in particle and VOC concentrations as well as the composition of VOCs, depending on the AM technique and feedstock. Levels of FeNO, IOS, and spirometry parameters were within clinical reference values for all AM operators. There was a difference in the relative abundance of saturated, notably dipalmitoylphosphatidylcholine (PC16:0_16:0), and unsaturated lung surfactant lipids in exhaled particles between controls and AM operators. ConclusionThere were no statistically significant differences between AM operators and controls for the different health examinations, which may be due to the low number of participants. However, the observed difference in the PC lipid profile in exhaled particles indicates a possible impact of the exposure and could be used as possible early biomarkers of adverse effects in the airways.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- additive manufacturing
- exposure
- nanoparticles
- exhaled air
- lung
- surfactant
- phosphatidylcholine
- exposure
- particles
- Public
- Environmental & Occupational Health
- additive manufacturing
Publication and Content Type
- ref (subject category)
- art (subject category)
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