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Normal neonatal TRE...
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Gudmundsdottir, J. A.Landspitali University Hospital,Natl Univ Hosp Reykjavik, Iceland
(author)
Normal neonatal TREC and KREC levels in early onset juvenile idiopathic arthritis
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/326515
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https://gup.ub.gu.se/publication/326515URI
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https://doi.org/10.1016/j.clim.2023.109277DOI
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https://research.chalmers.se/publication/535238URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152601391URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193997URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Funding Agencies|Icelandic Society of Rheumatology; Department of Pediatrics at the University of Gothenburg; Gothenburg Society of Medicine; Swedish Society of Medicine; Swedish Rheumatism Association; Swedish Research Council [2018-02752]; Queen Silvia Childrens Hospital Research Fund
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Objective: Dysregulated central tolerance predisposes to autoimmune diseases. Reduced thymic output as well as compromised central B cell tolerance checkpoints have been proposed in the pathogenesis of juvenile idiopathic arthritis (JIA). The aim of this study was to investigate neonatal levels of T-cell receptor excision circles (TRECs) and kappa-deleting element excision circles (KRECs), as markers of T-and B-cell output at birth, in patients with early onset JIA.Methods: TRECs and KRECs were quantitated by multiplex qPCR from dried blood spots (DBS), collected 2-5 days after birth, in 156 children with early onset JIA and in 312 matched controls.Results: When analysed from neonatal dried blood spots, the median TREC level was 78 (IQR 55-113) in JIA cases and 88 (IQR 57-117) copies/well in controls. The median KREC level was 51 (IQR 35-69) and 53 (IQR 35-74) copies/well, in JIA cases and controls, respectively. Stratification by sex and age at disease onset did not reveal any difference in the levels of TRECs and KRECs.Conclusion: T-and B-cell output at birth, as measured by TREC and KREC levels in neonatal dried blood spots, does not differ in children with early onset JIA compared to controls.
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Thorleifsson, Sigurdur,1980Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xtsigu
(author)
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Lundback, V.Karolinska Institutet,Karolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
(author)
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Gongrich, C.Karolinska Institutet,Karolinska universitetssjukhuset,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
(author)
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Lingman Framme, Jenny,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Halland Hosp Halmstad, Sweden(Swepub:gu)xlijer
(author)
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Kindgren, ErikLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Skaraborgs Hosp Skovde, Sweden(Swepub:liu)eriki51
(author)
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Rydenman, Karin,1982Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden(Swepub:gu)xrydek
(author)
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Ludviksson, B. R.Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
(author)
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Bjarnadottir, H.Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
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Runarsdottir, S.Landspitali University Hospital,Natl Univ Hosp Iceland, Iceland
(author)
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Nilsson, Staffan,1956Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden(Swepub:cth)staffan
(author)
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Zetterstrom, R. H.Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
(author)
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Ekwall, Olov,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden(Swepub:gu)xekwol
(author)
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Lindgren, Susanne,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,University of Gothenburg,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
(author)
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Thorgeirsdottir, SigridurGöteborgs universitet,University of Gothenburg,Univ Gothenburg, Sweden
(author)
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Landspitali University HospitalNatl Univ Hosp Reykjavik, Iceland
(creator_code:org_t)
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In:Clinical Immunology: Elsevier BV2491521-66161521-7035
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