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Blood-brain barrier...
Blood-brain barrier integrity impacts the use of plasma amyloid-beta as a proxy of brain amyloid-beta pathology
- Article/chapterEnglish2023
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LIBRIS-ID:oai:gup.ub.gu.se/327213
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https://gup.ub.gu.se/publication/327213URI
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https://doi.org/10.1002/alz.13014DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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INTRODUCTION Amyloid-beta (A beta) and tau can be quantified in blood. However, biological factors can influence the levels of brain-derived proteins in the blood. The blood-brain barrier (BBB) regulates protein transport between cerebrospinal fluid (CSF) and blood. BBB altered permeability might affect the relationship between brain and blood biomarkers.METHODS We assessed 224 participants in research (TRIAD, n = 96) and clinical (BIODEGMAR, n = 128) cohorts with plasma and CSF/positron emission tomography A beta, p-tau, and albumin measures.RESULTS Plasma A beta(42/40) better identified CSF A beta(42/40) and A beta-PET positivity in individuals with high BBB permeability. An interaction between plasma A beta(42/40) and BBB permeability on CSF A beta(42/40) was observed. Voxel-wise models estimated that the association of positron emission tomography (PET), with plasma A beta was most affected by BBB permeability in AD-related brain regions. BBB permeability did not significantly impact the relationship between brain and plasma p-tau levels.DISCUSSION These findings suggest that BBB integrity may influence the performance of plasma A beta, but not p-tau, biomarkers in research and clinical settings.
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Puig-Pijoan, A.
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Ferrari-Souza, J. P.
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Leffa, D. T.
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Lussier, F. Z.
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Ferreira, P. C. L.
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Tissot, C.
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Povala, G.
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Therriault, J.
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Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan
(author)
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Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Wallenberg Centre for Molecular and Translational Medicine,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn
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Servaes, S.
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Chamoun, M.
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Stevenson, J.
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Rahmouni, N.
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Vermeiren, M.
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Macedo, A. C.
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Fernandez-Lebrero, A.
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Garcia-Escobar, G.
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Navalpotro-Gomez, I.
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Lopez, O.
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Tudorascu, D. L.
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Cohen, A.
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Villemagne, V. L.
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Klunk, W. E.
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Gauthier, S.
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Zimmer, E. R.
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Karikari, ThomasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xkarit
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
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Suarez-Calvet, M.
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Rosa-Neto, P.
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Pascoal, T. A.
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
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In:Alzheimers & Dementia: Wiley19:9, s. 3815-38251552-52601552-5279
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Bellaver, B.
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Puig-Pijoan, A.
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Ferrari-Souza, J ...
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Leffa, D. T.
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Lussier, F. Z.
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Ferreira, P. C. ...
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Tissot, C.
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Povala, G.
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Therriault, J.
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Lessa Benedet, A ...
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Ashton, Nicholas ...
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Servaes, S.
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Chamoun, M.
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Stevenson, J.
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Rahmouni, N.
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Vermeiren, M.
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Macedo, A. C.
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Fernandez-Lebrer ...
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Garcia-Escobar, ...
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Navalpotro-Gomez ...
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Lopez, O.
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Tudorascu, D. L.
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Cohen, A.
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Villemagne, V. L ...
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Klunk, W. E.
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Gauthier, S.
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Zimmer, E. R.
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Karikari, Thomas
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Suarez-Calvet, M ...
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Rosa-Neto, P.
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Pascoal, T. A.
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