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Biological brain ag...
Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex
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Cumplido-Mayoral, I. (author)
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Garcia-Prat, M. (author)
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Operto, G. (author)
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Falcon, C. (author)
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Shekari, M. (author)
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Cacciaglia, R. (author)
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Mila-Aloma, M. (author)
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Lorenzini, L. (author)
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Ingala, S. (author)
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Wink, A. M. (author)
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Mutsaerts, H. J. (author)
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Minguillon, C. (author)
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Fauria, K. (author)
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Molinuevo, J. L. (author)
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Haller, S. (author)
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Chetelat, G. (author)
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Waldman, A. (author)
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Schwarz, A. J. (author)
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Barkhof, F. (author)
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Suridjan, I. (author)
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Kollmorgen, G. (author)
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Bayfield, A. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Suarez-Calvet, M. (author)
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Vilaplana, V. (author)
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Gispert, J. D. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Elife. - 2050-084X. ; 12
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https://gup.ub.gu.se...
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https://doi.org/10.7...
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Abstract
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- Brain--age can be inferred from structural neuroimaging and compared to chronological age (brain--age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's disease (AD), but its validation against markers of neurodegeneration and AD is lacking. Here, imaging--derived measures from the UK Biobank dataset (N=22,661) were used to predict brain--age in 2,314 cognitively unimpaired (CU) individuals at higher risk of AD and mild cognitive impaired (MCI) patients from four independent cohorts with available biomarker data: ALFA+, ADNI, EPAD, and OASIS. Brain-age delta was associated with abnormal amyloid-ss, more advanced stages (AT) of AD pathology and APOE-e4 status. Brain--age delta was positively associated with plasma neurofilament light, a marker of neurodegeneration, and sex differences in the brain effects of this marker were found. These results validate brain--age delta as a non-invasive marker of biological brain aging in non--demented individuals with abnormal levels of biomarkers of AD and axonal injury.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- brain age prediction
- neuroimaging
- alzheimer's disease
- Human
- white-matter hyperintensities
- neurofilament light
- cerebral-cortex
- mri
- scans
- associations
- signatures
- patterns
- network
- young
- Life Sciences & Biomedicine - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Elife
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To the university's database
- By the author/editor
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Cumplido-Mayoral ...
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Garcia-Prat, M.
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Operto, G.
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Falcon, C.
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Shekari, M.
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Cacciaglia, R.
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show more...
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Mila-Aloma, M.
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Lorenzini, L.
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Ingala, S.
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Wink, A. M.
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Mutsaerts, H. J.
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Minguillon, C.
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Fauria, K.
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Molinuevo, J. L.
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Haller, S.
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Chetelat, G.
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Waldman, A.
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Schwarz, A. J.
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Barkhof, F.
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Suridjan, I.
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Kollmorgen, G.
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Bayfield, A.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Suarez-Calvet, M ...
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Vilaplana, V.
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Gispert, J. D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Elife
- By the university
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University of Gothenburg