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COVID-19 hospitaliz...
COVID-19 hospitalization outcomes in adults by HIV status; a nation-wide register-based study
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- Moller, I. K. (author)
- Karolinska Institute,Karolinska University Hospital
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- Gisslén, Magnus, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Infect Dis, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Infect Dis, Region Vastra Gotaland, Gothenburg, Sweden.,Sahlgrenska Academy,Sahlgrenska University Hospital
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- Wagner, Philippe (author)
- Uppsala University,Lund University,Lunds universitet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Lund Univ, Dept Clin Sci, Lund, Sweden.,CPUP - barnortopedisk forskningsgrupp,Forskargrupper vid Lunds universitet,CPUP - Children's Orthopedics Group,Lund University Research Groups,Västmanland Hospital
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- Sparen, P. (author)
- Karolinska Institute
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- Carlander, C. (author)
- Uppsala University,Karolinska Institute,Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Karolinska Inst, Dept Med Huddinge, Div Infect Dis, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.,Karolinska University Hospital
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- English.
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In: Hiv Medicine. - : John Wiley & Sons. - 1464-2662 .- 1468-1293. ; 24:10, s. 1045-1055
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Abstract
Subject headings
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- Objectives: To assess the outcome of patients hospitalized with COVID-19 by HIV status and risk factors for severe COVID-19 in people living with HIV (PWH), we performed a nationwide cohort study using register data. Methods: All people aged >= 18 years hospitalized with a primary COVID-19 diagnosis (U07.1 or U07.2) in Sweden between February 2020 and October 2021 were included. The primary outcome was severe COVID-19 [intensive care unit (ICU) admission or 90-day mortality]. Secondary outcomes were days in hospital and ICU, complications in hospital, and risk factors for severe COVID-19 in PWH. Regression analyses were performed to assess severe COVID-19 by HIV status and risk factors. Results: Data from 64 815 hospitalized patients were collected, of whom 121 were PWH (0.18%). PWH were younger (p < 0.001), and larger proportions were men (p = 0.014) and migrants (p < 0.001). Almost all PWH had undetectable HIV-RNA (93%) and high CD4 T-cell counts (median = 560 cells/mu L, interquartile range: 376-780). In an unadjusted model, PWH had statistically significant lower odds of severe COVID-19 compared with patients without HIV [odds ratio (OR) = 0.6, 95% confidence interval (CI): 0.34-0.94], but there was no significant difference after adjusting for age and comorbidity (adjusted OR = 0.7, 95% CI: 0.43-1.26). A statistically significant lower proportion of PWH (8%, 95% CI: 5-15%) died within 90 days compared with those without HIV (16%, 95% CI: 15-16%, p = 0.024). There was no statistically significant difference in days in hospital and complications during the hospital stay between PWH and patients without HIV. Conclusions: In this nationwide study including well-treated PWH, HIV was not a risk factor in hospitalized patients for developing severe COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- COVID-19
- HIV
- hospitalization
- mortality
- SARS-CoV-2
- coronavirus disease 2019
- risk-factors
- comorbidities
- cohort
- infection
- death
- Infectious Diseases
- COVID-19
Publication and Content Type
- ref (subject category)
- art (subject category)
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