Search: onr:"swepub:oai:gup.ub.gu.se/327568" >
C-type lectin recep...
C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates
-
Vono, M. (author)
-
Mastelic-Gavillet, B. (author)
-
Mohr, E. (author)
-
show more...
-
- Östensson, Malin, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
- Persson, Josefine, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
Olafsdottir, T. A. (author)
-
Lemeille, S. (author)
-
Pejoski, D. (author)
-
Hartley, O. (author)
-
Christensen, D. (author)
-
Andersen, P. (author)
-
Didierlaurent, A. M. (author)
-
- Harandi, Ali M, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
-
Lambert, P. H. (author)
-
Siegrist, C. A. (author)
-
show less...
-
(creator_code:org_t)
- 2023-03-31
- 2023
- English.
-
In: FRONTIERS IN IMMUNOLOGY. - : Frontiers Media SA. - 1664-3224. ; 14
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Introduction: C-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults. Methods: Here, we explored the mechanisms accounting for the differences in neonatal adjuvanticity between a CLR-based (CAF (R) 01) and a TLR4-based (GLA-SE) adjuvant administered with influenza hemagglutinin (HA) in neonatal mice, by using transcriptomics and systems biology analyses. Results: On day 7 after immunization, HA/CAF01 increased IL6 and IL21 levels in the draining lymph nodes, while HA/GLA-SE increased IL10. CAF01 induced mixed Th1/Th17 neonatal responses while T cell responses induced by GLA-SE had a more pronounced Th2-profile. Only CAF01 induced T follicular helper (Tfh) cells expressing high levels of IL21 similar to levels induced in adult mice, which is essential for germinal center (GC) formation. Accordingly, only CAF01-induced neonatal Tfh cells activated adoptively transferred hen egg lysozyme (HEL)specific B cells to form HEL+ GC B cells in neonatal mice upon vaccination with HEL-OVA. Discussion: Collectively, the data show that CLR-based adjuvants are promising neonatal and infant adjuvants due to their ability to harness Tfh responses in early life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- T follicular helper (Tfh)
- interleukin-6 (IL-6)
- interleukin-21 (IL-21)
- vaccine adjuvants
- C-type lectin receptor agonists
- toll-like receptor
- agonists
- neonatal vaccinology
- follicular-helper-cells
- dendritic cells
- t-cells
- antibody-production
- il-21
- differentiation
- interleukin-21
- generation
- expression
- distinct
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Vono, M.
-
Mastelic-Gaville ...
-
Mohr, E.
-
Östensson, Malin ...
-
Persson, Josefin ...
-
Olafsdottir, T. ...
-
show more...
-
Lemeille, S.
-
Pejoski, D.
-
Hartley, O.
-
Christensen, D.
-
Andersen, P.
-
Didierlaurent, A ...
-
Harandi, Ali M, ...
-
Lambert, P. H.
-
Siegrist, C. A.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
FRONTIERS IN IMM ...
- By the university
-
University of Gothenburg